The #1 Longevity Community
Commonly used drug may extend women’s fertility, claim researchers – here’s what you need to know about rapamycin
<div><figure><img src="https://images.theconversation.com/files/609648/original/file-20240726-19-3p20kj.jpg?ixlib=rb-4.1.0&rect=0%2C13%2C8843%2C5873&q=45&auto=format&w=496&fit=clip"><figcaption><span class="caption">For women, fertility begins to decline by age 35.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-photo/african-american-woman-pregnancy-uterine-tube-2043166517">Andrey_Popov/ Shutterstock</a></span></figcaption></figure><p>A <a href="https://time.com/6965267/women-having-kids-later/">growing number of people</a> are waiting longer to have kids. While there are many reasons people may want to hold back on that decision, <a href="https://www.reproductivefacts.org/news-and-publications/fact-sheets-and-infographics/ovarian-reserve-predicting-fertility-potential-in-women/">about one-third of couples</a> will have difficulties getting pregnant if the female partner is over 35. This is because women’s fertility begins <a href="https://www.britishfertilitysociety.org.uk/fei/at-what-age-does-fertility-begin-to-decrease/">declining around that age</a>. </p>
<p>But the researchers of an <a href="https://clinicaltrials.gov/study/NCT05836025">ongoing clinical trial</a> claim rapamycin, a drug commonly used to prevent organ transplants from failing, may be able to extend a <a href="https://www.theguardian.com/society/article/2024/jul/22/drug-women-fertility-study-rapamycin">woman’s fertile years</a> by up to five years. This is based on the early communication of results from the small pilot study they conducted, which has not yet been peer reviewed.</p>
<p>While it’s still too early to say whether rapamycin could be the future of fertility treatments – we’ll need to wait two years now for the clinical trial to finish – there is some reason to be optimistic about the findings they’ve reported. Numerous studies in mice have shown rapamycin is beneficial for many aspects of ageing – including fertility.</p>
<p>Future fertility can originate before birth. While in the mother’s womb, female gametes (eggs) surrounded by specialised cells in the ovaries form “primordial follicles”. Each follicle contains a single egg which enters into a dormant state until it’s recruited for use at puberty.</p>
<p>Numerous follicles die even before birth. This means that every women is born with all the follicles she will ever have. This is known as the “<a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ovarian-reserve">ovarian reserve</a>”. This early-established ovarian reserve can affect a person’s ability to become pregnant <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737352/">throughout their reproductive years</a>.</p>
<p>During each menstrual cycle, several dozens of follicles will be recruited (selected) – but only a single dominant follicle will release its egg to be fertilised. The other recruited follicles <a href="https://rep.bioscientifica.com/view/journals/rep/162/2/REP-21-0022.xml">will be degraded</a> by the ovary. As a woman ages, her <a href="https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-023-01151-z">ovarian reserve diminishes</a> until she has only a limited number of good-quality follicles remaining. At this point, some ovarian hormones circulating in her body decrease, initiating menopause. </p>
<p>The average age of <a href="https://www.webmd.com/menopause/menopause-information">menopause is 51 years</a> – though this can vary broadly between women depending on their ovarian reserve. Some women experience <a href="https://www.nhs.uk/conditions/early-menopause/">early menopause</a> (which happens before the age of 45). Around 1% of women may even experience <a href="https://my.clevelandclinic.org/health/diseases/21138-premature-and-early-menopause">premature menopause</a>, which happens before 40. Since menopause directly affects fertility, early menopause could seriously affect a woman’s parenting plans. </p>
<p>But if it were possible to delay ovarian ageing, this could extend a woman’s fertility. This is something <a href="https://www.newscientist.com/definition/rapamycin">rapamycin</a> may be able to do. </p>
<h2>Re-purposing rapamycin</h2>
<p>Rapamycin is a bacterial compound that allows cells to survive longer in lab settings. </p>
<p>It’s commonly used in organ transplant patients to dampen their immune system so that the body doesn’t reject the new organ. It’s also used to treat <a href="https://www.gosh.nhs.uk/conditions-and-treatments/medicines-information/oral-sirolimus-treat-vascular-problems/">certain vascular conditions</a> by slowing down cell growth (such as tumour).</p>
<p>A growing body of evidence shows rapamycin may also have benefits when it comes to ageing. </p>
<p>Research in mice shows it can <a href="https://www.nature.com/articles/s41467-022-29714-6#:~:text=Calorie%20restriction%20%28CR%29%20potently%20extends%20health%20and%20lifespan%2C,and%20is%20proven%20to%20counteract%20age-related%20muscle%20loss.">counteract age-related muscle loss</a>. A daily dose of rapamycin has also been shown to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190242/">improve the lifespan of older mice by 10%</a>. </p>
<p>When it comes to fertility, studies have demonstrated that a daily dose of rapamycin <a href="https://pubmed.ncbi.nlm.nih.gov/29330421/">delays ovarian ageing and menopause</a> in mice. Older female mice who were given a diet containing rapamycin had an increase in their pool of primordial follicles – the ovarian reserve. Moreover, these mice also had successful litters later in life. This suggested that rapamycin could have the potential to delay premature menopause in women.</p>
<figure class="align-center ">
<img alt="A mouse sits on top of a person's hand." src="https://images.theconversation.com/files/609650/original/file-20240726-19-d6dq24.jpg?ixlib=rb-4.1.0&q=45&auto=format&w=754&fit=clip" srcset="https://images.theconversation.com/files/609650/original/file-20240726-19-d6dq24.jpg?ixlib=rb-4.1.0&q=45&auto=format&w=600&h=400&fit=crop&dpr=1 600w, https://images.theconversation.com/files/609650/original/file-20240726-19-d6dq24.jpg?ixlib=rb-4.1.0&q=30&auto=format&w=600&h=400&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/609650/original/file-20240726-19-d6dq24.jpg?ixlib=rb-4.1.0&q=15&auto=format&w=600&h=400&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/609650/original/file-20240726-19-d6dq24.jpg?ixlib=rb-4.1.0&q=45&auto=format&w=754&h=503&fit=crop&dpr=1 754w, https://images.theconversation.com/files/609650/original/file-20240726-19-d6dq24.jpg?ixlib=rb-4.1.0&q=30&auto=format&w=754&h=503&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/609650/original/file-20240726-19-d6dq24.jpg?ixlib=rb-4.1.0&q=15&auto=format&w=754&h=503&fit=crop&dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px">
<figcaption>
<span class="caption">Research in mice has shown the drug is beneficial to ovarian ageing.</span>
<span class="attribution"><a class="source" href="https://www.shutterstock.com/image-photo/laboratory-mouse-on-researchers-hand-animal-556378882">unoL/ Shutterstock</a></span>
</figcaption>
</figure>
<p>But can the drug do the same in humans? This is what a research team has <a href="https://www.businessinsider.com/rapamycin-antiaging-drug-for-ovaries-infertility-2023-4">set out to investigate</a>. The team recruited 50 women aged 35-45 years, who were perimenopausal, to their <a href="https://clinicaltrials.gov/study/NCT05836025">pilot study</a>.</p>
<p>For three months, women either received a weekly dose of rapamycin or a placebo. The ovarian reserve was monitored by transvaginal ultrasound and several blood tests to detect various ovarian hormones.</p>
<p>The researchers claim the <a href="https://www.theguardian.com/society/article/2024/jul/22/drug-women-fertility-study-rapamycin">initial results</a> were very encouraging – suggesting that the drug might decrease ovarian ageing by 20% in women without any side-effects from the drug. The researchers hope that this could mean an additional five years of fertility.</p>
<p>Rapamycin might trigger this positive effect by restricting the number of primordial follicles being recruited and activated per menstrual cycle. In women who received rapamycin, only 15 follicles were recruited per menstrual cycle – compared to 50 in women at similar age. With less follicle recruitment, the ovarian reserve seems to be prolonged.</p>
<p>Previous research in mice has shown that rapamycin <a href="https://doi.org/10.1016/j.mce.2019.110694">recruits fewer follicles</a>, which may preserve ovarian reserve.</p>
<h2>Maintaining fertility</h2>
<p>The cohort size of the initial study was rather small. But given the promising results the researcher claim to have had, this means they will now be able to move into the next phase of their experiment – recruiting 1,000 women. </p>
<p>Hopefully the initial results will be confirmed again and show that rapamycin is a useful treatment for ovarian ageing in a peer-reviewed study. Additional studies will then be needed to investigate whether this fertility is prolonged.</p>
<p>But if the clinical trial shows rapamycin is beneficial, this could help women with low ovarian reserve and those hoping to prolong their fertility.</p>
<p>Moreover, this study highlights the potential of re-purposing existing drugs to treat other conditions for women’s health and wellbeing. This is something <a href="https://srf-reproduction.org/grants-awards/awards/srf-student-prize/">my team members and I</a> are doing at the University of Central Lancashire, as well. We’re currently investigating in cells whether re-purposing commonly used diabetes drugs can improve the uterus and make it easier for an embryo to implant itself. We’re also investigating these targets to treat ovarian cancer.</p><img src="https://counter.theconversation.com/content/235370/count.gif" alt="The Conversation" width="1" height="1">
<p class="fine-print"><em><span>Dr Stéphane Berneau receives funding from the Society for Reproduction and Fertility (SRF) & the Biochemical Society.
Dr Stéphane Berneau is a member of the Society for Reproduction and Fertility (SRF), the Biochemical Society, Alzheimer's Research UK and Anatomical Society</span></em></p></div>
Octopus and squid pigment xanthochrome boosts sunscreen efficacy when combined with zinc oxide
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/Octopus-with-sunscreen.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="Octopus and squid pigment xanthochrome boosts sunscreen efficacy when combined with zinc oxide" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>A recent study published in the <em><a target="_blank" href="https://onlinelibrary.wiley.com/doi/10.1111/ics.12993" rel="noreferrer noopener">International Journal of Cosmetic Science</a> </em>uncovered a promising development in sunscreen technology.</p>
<p>The study reveals that xanthochrome, a pigment found in octopuses and squids, can significantly enhance the effectiveness of sunscreen when combined with zinc oxide.</p>
<p>This discovery can potentially revolutionize <a href="https://longevity.technology/lifestyle/sunscreen-savvy-the-basic-guide-to-summer-skin-protection/" target="_blank" rel="noreferrer noopener">sun protection</a> products, opening new avenues for their improvement [<a href="https://onlinelibrary.wiley.com/doi/10.1111/ics.12993" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>Xanthochrome, which contributes to the vibrant yellow and orange hues in marine cephalopods, has been identified as a powerful agent that offers superior protection against ultraviolet (UV) radiation when mixed with zinc oxide [<a target="_blank" href="https://www.ncbi.nlm.nih.gov/books/NBK526048/" rel="noreferrer noopener">2</a>]. Zinc oxide is a common ingredient in sunscreens known for its broad-spectrum UV filtering properties, but adding xanthochrome can further enhance its protective qualities [<a target="_blank" href="https://cosmetics.specialchem.com/inci-ingredients/zinc-oxide" rel="noreferrer noopener">3</a>].</p>
<p>In the study, the team tested various sunscreen formulations containing both xanthochrome and zinc oxide. They found that this combination significantly increased the sunscreen’s ability to absorb and block UV rays, potentially reducing the risk of skin damage and sunburn.</p>
<p>The researchers credit this improvement to xanthochrome’s unique chemical structure, which interacts synergistically with zinc oxide to enhance UV absorption.</p>
<p>This finding is a scientific discovery and a potential game-changer for the skincare industry. It could lead to developing more <a href="https://longevity.technology/lifestyle/what-dermatologists-wish-you-knew-about-your-sunscreen/" target="_blank" rel="noreferrer noopener">effective sunscreens</a>, which are crucial for preventing skin cancer and premature aging caused by sun exposure [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759112/" target="_blank" rel="noreferrer noopener">4</a>].</p>
<p>The study suggests that incorporating natural pigments like xanthochrome into sunscreen formulations could significantly create more efficient sun protection products.</p>
<p>Overall, the integration of xanthochrome with zinc oxide represents an innovative approach to boosting sunscreen performance, offering a potential enhancement to the safety and efficacy of sun protection solutions.</p>
<p>[1] International Journal of Cosmetic Science. <a href="https://onlinelibrary.wiley.com/doi/10.1111/ics.12993" target="_blank" rel="noreferrer noopener">Using cephalopod-inspired chemistry to extend long-wavelength ultraviolet and visible light protection of mineral sunscreens</a><br>[2] StatPearls. <a href="https://www.ncbi.nlm.nih.gov/books/NBK526048/" target="_blank" rel="noreferrer noopener">Xanthochromia</a><br>[3] Special Chem. <a href="https://cosmetics.specialchem.com/inci-ingredients/zinc-oxide" target="_blank" rel="noreferrer noopener">Zinc oxide</a><br>[4] Canadian Medical Association Journal. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759112/" target="_blank" rel="noreferrer noopener">The efficacy and safety of sunscreen use for the prevention of skin cancer</a></p>
<p>The post <a href="https://longevity.technology/lifestyle/octopus-and-squid-pigment-xanthochrome-boosts-sunscreen-efficacy-when-combined-with-zinc-oxide/">Octopus and squid pigment xanthochrome boosts sunscreen efficacy when combined with zinc oxide</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
Game of Thrones helped decode brain’s facial recognition system in study
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/Brain-Image-with-game-of-thrones-theme.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="Game of Thrones helped decode brain’s facial recognition system in study" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>In a groundbreaking study, researchers discovered that familiarity with characters from the popular TV series <em>“<a href="https://www.hbo.com/game-of-thrones" target="_blank" rel="noreferrer noopener">Game of Thrones</a>“</em> significantly enhances functional connectivity between visual and nonvisual regions of the brain. </p>
<p>This research, conducted by a team from the University of York, revealed that viewers familiar with the show’s characters showed marked differences in neural connectivity compared to those unfamiliar with the series [<a href="https://academic.oup.com/cercor/article-abstract/34/7/bhae285/7717960" target="_blank" rel="noreferrer noopener">1</a>].</p>
<h2 class="wp-block-heading" id="h-research-overview"><strong>Research overview</strong></h2>
<p>The study employed functional magnetic resonance imaging (fMRI) to examine the brain activity of participants while they watched clips from <em>“Game of Thrones.”</em> By using familiar and unfamiliar faces, the researchers aimed to investigate the neural mechanisms underlying facial recognition. </p>
<p>The choice of <em>“Game of Thrones”</em> was particularly strategic, as the show’s diverse and memorable cast provided a rich set of stimuli for studying facial recognition processes.</p>
<p>Dr. Kira N. Noad, the lead researcher, explained, <em>“We chose to show participants footage from Game of Thrones because the series captivated people around the world with its strong characters and their deeply nuanced personalities.”</em></p>
<p><em>“Many previous studies on the mechanisms in the brain behind facial recognition have been done in laboratory settings with 2D static images of faces. We aimed to create a study format that was more like real life, using video to show complex scenes with multiple people.</em></p>
<p><em>“We now need to carry out further studies to explore in more detail how activity across different regions of the brain allows us to recognize faces as well as what factors can disrupt this process.” </em>[<a href="https://www.york.ac.uk/news-and-events/news/2024/research/game-of-thrones-face-blindness/" target="_blank" rel="noreferrer noopener">2</a>]</p>
<p>The study utilized intersubject correlation (ISC) and functional connectivity analysis to measure neural responses, offering a comprehensive view of how the brain processes familiar versus unfamiliar faces [<a href="https://academic.oup.com/cercor/article-abstract/34/7/bhae285/7717960" target="_blank" rel="noreferrer noopener">1</a>].</p>
<h2 class="wp-block-heading" id="h-study-findings-nbsp"><strong>Study findings </strong></h2>
<p>The findings were remarkable, revealing that familiarity with faces enhances functional connectivity in the brain’s face-processing network. This network includes areas such as the fusiform face area (FFA) and the anterior temporal lobes, which are crucial for recognizing and processing faces. </p>
<p>Participants familiar with <em>“Game of Thrones”</em> characters exhibited more synchronized neural responses, suggesting a more efficient and integrated neural processing system.</p>
<p>This insight provides valuable understanding into conditions like prosopagnosia, where individuals have difficulty recognizing familiar faces, and suggests potential directions for therapeutic interventions [<a href="https://academic.oup.com/cercor/article-abstract/34/7/bhae285/7717960" target="_blank" rel="noreferrer noopener">1</a>].</p>
<h2 class="wp-block-heading" id="h-expert-insights-nbsp"><strong>Expert insights </strong></h2>
<p>Dr. Timothy J. Andrews, senior author of the study, highlighted the potential implications of these findings [<a href="https://neurosciencenews.com/neuroscience-face-blindness-got-26476/" target="_blank" rel="noreferrer noopener">3</a>]: </p>
<p><em>“We were really excited to see the results of our study as they suggest that our ability to recognize faces relies on what we know about people, not just what they look like.”</em></p>
<p><em>“While it was believed that we recognize faces by learning their visual properties—such as features, configuration, and texture—our study indicates that it involves connecting a face with knowledge about the person, including their character traits, body language, our personal experiences with them, and our feelings towards them.</em></p>
<p><em>“Facial recognition is essential for daily life and social interactions. When people struggle with this, it can significantly impact their lives and relationships, often leading to mental health issues and social anxiety.</em></p>
<p><em>“Our research enhances the understanding of how prosopagnosia appears to be linked to reduced neural connections, making it challenging to associate faces with personal knowledge, which is crucial for recognition.”</em></p>
<p>Future research could explore how different types of familiarity—such as familiarity with voices, places, or objects—affect neural connectivity. </p>
<p>Additionally, examining how these findings apply across different demographics, including age groups and cultural backgrounds, could provide a more comprehensive understanding of the neural mechanisms at play.</p>
<p>This study represents a significant step forward in understanding the brain’s facial recognition system. By leveraging the cultural phenomenon of <em>“Game of Thrones,”</em> researchers have uncovered critical insights into how familiarity enhances neural connectivity. Studies like this one will be invaluable in guiding future discoveries and applications.</p>
<p>[1] Cerebral Cortex. <a href="https://academic.oup.com/cercor/article-abstract/34/7/bhae285/7717960" target="_blank" rel="noreferrer noopener">Familiarity enhances functional connectivity between visual and nonvisual regions of the brain during natural viewing </a> <br>[2] University of York. <a href="https://www.york.ac.uk/news-and-events/news/2024/research/game-of-thrones-face-blindness/" target="_blank" rel="noreferrer noopener">Study uses Game of Thrones to advance understanding of face blindness</a><br>[3] Neuroscience News. <a href="https://neurosciencenews.com/neuroscience-face-blindness-got-26476/" target="_blank" rel="noreferrer noopener">Researchers Use Game of Thrones to Study Face Blindness</a></p>
<p>The post <a href="https://longevity.technology/lifestyle/game-of-thrones-helped-decode-brains-facial-recognition-system-in-study/">Game of Thrones helped decode brain’s facial recognition system in study</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
Gene editing may be the potential cure for progeria, a condition causing rapid aging in children
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/Gene-Editing.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="Gene editing may be the potential cure for progeria, a condition causing rapid aging in children" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>Researchers are investigating gene editing as a potential treatment for progeria, a rare genetic disorder that causes rapid aging in children [<a target="_blank" href="https://www.nature.com/articles/s41586-020-03086-7" rel="noreferrer noopener">1</a>].</p>
<p>This condition, called Hutchinson-Gilford progeria syndrome (HGPS), results from a mutation in the LMNA gene [<a target="_blank" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406247/" rel="noreferrer noopener">2</a>]. This mutation produces a toxic protein called progerin that accelerates aging.</p>
<p>Recent studies have demonstrated significant progress using adenine base editors (ABEs) to correct the mutation responsible for progeria. A study published in <em><a target="_blank" href="https://www.nature.com/articles/s41586-020-03086-7" rel="noreferrer noopener">Nature</a></em> in 2021 describes the application of ABEs in both cultured fibroblasts and a mouse model of HGPS.</p>
<p>This approach targets and corrects the specific mutation in the LMNA gene that causes the disease. The study found that using lentiviral delivery to treat fibroblasts from patients with HGPS achieved an 87-91% correction rate of the mutation.</p>
<p>It also reduced progerin levels, improved cell function, and fixed abnormal cell structures. Notably, the analysis confirmed that there were no unintended side effects.</p>
<p>The latest developments, highlighted in a <em><a target="_blank" href="https://www.nytimes.com/2024/07/24/health/progeria-dna-base-editing.html" rel="noreferrer noopener">New York Times</a></em> article, report that researchers are now focusing on optimizing the delivery systems for ABEs to treat patients directly. This includes refining methods to administer ABEs effectively and safely to human cells.</p>
<p>The advancements are still experimental but suggest a viable pathway toward clinical application [<a target="_blank" href="https://www.nytimes.com/2024/07/24/health/progeria-dna-base-editing.html" rel="noreferrer noopener">3</a>].</p>
<p>A single injection of a particular virus carrying the ABE corrected the mutation in various organs in mice. This treatment fixed the faulty RNA, reduced harmful protein levels, and significantly extended the mice’s median lifespan from 215 to 510 days, showing its potential effectiveness.</p>
<p>These findings highlight the promise of in vivo base editing to treat progeria and other genetic disorders by directly addressing their genetic causes.</p>
<p>[1] Nature<em>. </em><a href="https://www.nature.com/articles/s41586-020-03086-7" target="_blank" rel="noreferrer noopener">In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice</a><br>[2] Cells. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406247/" target="_blank" rel="noreferrer noopener">Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment</a><br>[3] New York Times. <a href="https://www.nytimes.com/2024/07/24/health/progeria-dna-base-editing.html" target="_blank" rel="noreferrer noopener">A Disease That Makes Children Age Rapidly Gets Closer to a Cure</a></p>
<p>The post <a href="https://longevity.technology/lifestyle/gene-editing-may-be-the-potential-cure-for-progeria-a-condition-causing-rapid-aging-in-children/">Gene editing may be the potential cure for progeria, a condition causing rapid aging in children</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
Cellular Reprogramming Improves Cognition in Aged Rats
<div><p style="text-align: justify;">Scientists have shown that prolonged, continuous expression of reprogramming factors <a href="https://pubmed.ncbi.nlm.nih.gov/39037528/">counters cognitive decline in old rats</a> and probably decreases their epigenetic age [1].</p>
<div id="playht-iframe-wrapper" style="display:flex; max-height:90px; justify-content:center">
<iframe allowfullscreen="" frameborder="0" scrolling="no" class="playht-iframe-player" data-appid="E9FaMfn-qe" article-url="https://www.lifespan.io/?p=130905" data-voice="en-US-BrandonNeural" src="https://play.ht/embed/?article_url=https://www.lifespan.io/?p=130905&voice=en-US-BrandonNeural&config=%7B%22width%22:%22100%%22,%22height%22:%2290px%22,%22alignment%22:%22center%22,%22title%22:%22Audio%22,%22message%22:%22Hello%22,%22download_text_button%22:%22Download%22%7D" width="100%" height="90px" style="max-height:90px">
</iframe>
</div>
<h2 style="text-align: justify;"><b>Reprogramming and cognitive function</b></h2>
<p style="text-align: justify;">Cellular reprogramming, the act of bringing differentiated cells back to a stem-like pluripotent state by expressing certain genes, has been one of the hottest subfields in longevity in recent years. Reprogramming, which can be either full or partial, also results in cellular rejuvenation.</p>
<p style="text-align: justify;"></p><div class="wpv-grid grid-1-1 wpv-first-level unextended animation-from-left"><div class="topic-box-item" style="background-color:#fff"><a href="https://www.lifespan.io/topic/yamanaka-factors/" class="topic-thumb-link"><div class="topic-box-thumb-wrap topic-thumb-align-left"><div class="topic-box-thumb" style="background:url(https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells.jpg) no-repeat center center;background-size: contain;"><img fetchpriority="high" decoding="async" width="800" height="450" src="https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells.jpg" class="attachment-full size-full wp-post-image" alt="Stem cells" srcset="https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells.jpg 800w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-400x225.jpg 400w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-704x396.jpg 704w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-256x144.jpg 256w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-300x169.jpg 300w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-150x84.jpg 150w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-480x270.jpg 480w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-600x338.jpg 600w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-360x203.jpg 360w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-262x147.jpg 262w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-555x312.jpg 555w, https://www.lifespan.io/wp-content/uploads/2020/10/stem-cells-768x432.jpg 768w" sizes="(max-width: 800px) 100vw, 800px"></div></div></a><a class="topic-info-link" href="https://www.lifespan.io/topic/yamanaka-factors/"><div class="topic-box-title">Yamanaka Factors - Opportunities for Rejuvenation</div><div class="topic-box-desc">Drs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed that cellular identity and aging could be reset with just four reprogramming factors, it causes cells to forget their functions and organs. However, exposure to reprogramming factors for just long enough can reverse the age of a cell without erasing its identity. This is the basis of partial cellular reprogramming.<br><span class="topi-read-more">Read More</span></div></a></div></div>
<p style="text-align: justify;">Numerous studies have shown that reprogramming can increase healthspan and lifespan in animal models. However, in vivo reprogramming can also lead to disease and death due to harsh side effects [2]. Creating effective and safe reprogramming protocols is very much a work in progress.</p>
<p style="text-align: justify;">One aspect that has not received a lot of attention is the impact of cellular reprogramming on age-related cognitive decline. In this new study published in <i>GeroScience</i>, researchers delivered viral vectors carrying the four “classic” reprogramming factors known as OSKM into the hippocampi of aged female rats. A month after the injections, the researchers ran tests to ascertain their effects on the animals’ cognitive function.</p>
<p style="text-align: justify;">Unlike creating transgenic OSKM-expressing mice, introducing OSKM via viral vectors has a good safety profile, at least for now. As their inspiration, the authors mention “the pioneering results achieved by David Sinclair’s team employing OSK gene therapy in the retina of mice.” [3] Sinclair’s group had omitted the fourth factor, <i>c-Myc</i>, because of its cancer-causing (oncogenic) potential, but in this new study, the researchers used the full four-factor cocktail.</p>
<h2 style="text-align: justify;"><b>You can teach an old rat new tricks</b></h2>
<p style="text-align: justify;">The researchers employed the Barnes memory test to assess learning performance and spatial memory. During six acquisition training (AT) sessions, the rats were tasked with locating an escape box within two minutes, which was concealed beneath one of 20 holes around the edge of the platform.</p>
<p><img decoding="async" class="aligncenter size-full wp-image-130908" src="https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition.png" alt="OSKM on Cognition" width="1000" height="740" srcset="https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition.png 1000w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-400x296.png 400w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-535x396.png 535w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-256x189.png 256w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-300x222.png 300w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-150x111.png 150w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-480x355.png 480w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-600x444.png 600w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-360x266.png 360w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-262x194.png 262w, https://www.lifespan.io/wp-content/uploads/2024/07/OSKM-on-Cognition-555x411.png 555w" sizes="(max-width: 1000px) 100vw, 1000px"></p>
<p style="text-align: justify;">Old untreated rats showed marked cognitive decline compared to young animals. While young animals learned the location of the escape hole quickly, and their results plateaued after three to five trials, their aged counterparts seemed to have lost this learning ability almost completely.</p>
<p style="text-align: justify;">The OSKM-treated rats were somewhere in the middle, demonstrating notable improvement on the fifth and the sixth attempts, although still not on par with the young animals. After an improvement on AT2, the results worsened on AT3 and AT4, which the researchers do not have a definitive explanation for yet.</p>
<p style="text-align: justify;">Steve Horvath, a renowned geroscientist currently with UCLA and Altos Labs, and the corresponding author on the study, told Lifespan.io that “there might have been a major stress response that initially negated the beneficial effects. Once the stress response subsided, the benefits became apparent. In other words, it could be a hormesis effect at the level of brain cells.”</p>
<p style="text-align: justify;">The second lead author, Rodolfo Goya of the National University of La Plata in Argentina, suggested that the AT2 value might have been noisy and that the real statistically significant improvement in the study group occurred starting with AT5.</p>
<p style="text-align: justify;">The expression of the OSKM genes in the dentate gyrus, a hippocampal region, was detectable for at least four weeks after the injection. According to the paper, “39 days of continuous OSKM expression induced no pathological alterations in the hippocampal parenchyma or other brain regions.”</p>
<h2 style="text-align: justify;"><b>Mild biological age decrease</b></h2>
<p style="text-align: justify;">The researchers then investigated whether the treatment had led to a decrease in biological age versus controls, as measured by three different epigenetic clocks. Such clocks, pioneered by Horvath himself, are based on DNA methylation patterns that are known to correlate with chronological age and mortality. According to the clocks, the treatment led to mild rejuvenation. The difference was statistically significant when a one-tailed p-value test was used – in other words, where only the possibility of the treatment lowering biological age, but not of increasing it, was considered.</p>
<p style="text-align: justify;">“I find it very surprising that this gene therapy seems to rejuvenate both cognitive function and the methylation patterns of the hippocampus,” Horvath said. “This paper contributes to the growing body of literature suggesting that interrupted reprogramming could have beneficial effects on the brain.”</p>
<blockquote>
<p style="text-align: justify;">In our study, we specifically investigated the effects of OSKM gene delivery on hippocampal DNA methylation. We found suggestive evidence of epigenetic rejuvenation, corroborated by two separate epigenetic clocks designed specifically for rat and mouse brain samples. These findings align with numerous studies that have also reported signs of epigenetic rejuvenation in human and mouse cells and tissues following OSKM or OSK application. While our sample size was limited (n=8 old OSKM-treated samples versus n=6 old controls), these epigenetic clocks, trained using independent data, provide insights due to their accuracy.</p>
</blockquote>
<div class="textwidget"><div class="life-highlight-box lhbox-has-zoom-yes l-hbox-size-large l-hbox-edges-square" style="background-color: #142e96;"><div class="l-hbox-lower"><div class="l-hbox-lower-title"><a href="https://www.lifespan.io/how-you-can-help/" target="_self" rel="noopener"><span style="color:#FFFFFF;">Our nonprofit mission is to increase healthy human lifespan, for everyone!</span></a></div><div class="l-hbox-lower-desc" style="color:#FFFFFF;">To do this, we need your support. Your charitable contribution tranforms into rejuvenation research, news, shows, and more. <strong>Will you help?</strong></div><style>.rb--7c648868816178 a {background-color:#bf5615;}.rb--7c648868816178 a:hover {background-color:#1f7d22;}</style><div class="l-hbox-lower-cta rb--7c648868816178"><a href="https://www.lifespan.io/how-you-can-help/" target="_self" rel="noopener"><strong>♥ Yes, I'll Donate</strong></a></div></div></div>
</div>
<h2 style="text-align: justify;"><b>Literature</b></h2>
<p style="text-align: justify;">[1] Horvath, S., Lacunza, E., Mallat, M. C., Portiansky, E. L., Gallardo, M. D., Brooke, R. T., … & Goya, R. G. (2024). Cognitive rejuvenation in old rats by hippocampal oskm gene therapy. GeroScience, 1-15.</p>
<p style="text-align: justify;">[2] Parras, A., Vílchez-Acosta, A., Desdín-Micó, G., Picó, S., Mrabti, C., Montenegro-Borbolla, E., … & Ocampo, A. (2023). In vivo reprogramming leads to premature death linked to hepatic and intestinal failure. Nature Aging, 3(12), 1509-1520.</p>
<p style="text-align: justify;">[3] Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., … & Sinclair, D. A. (2020). Reprogramming to recover youthful epigenetic information and restore vision. Nature, 588(7836), 124-129.</p></div>
Lord Lebedev advocates for longevity research in House of Lords
As a trustee of the Hevolution Foundation, Lord Lebedev noted he is deeply invested in longevity research – an area he believes could transform the medical landscape of the country. Longevity.Technology: In an era where life expectancy continues to rise, policymakers are increasingly recognizing the importance of ensuring that the years added to life are spent in good health. This growing awareness underscores the critical need for advancing research that not only extends lifespan but also impro
How does magnesium deficiency affect your daily life?
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/06/inscription-mg-and-natural-ingredients-containing-2023-11-27-05-02-28-utc-ratmaner-Envato.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="How does magnesium deficiency affect your daily life?" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="(max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px">
<p><strong>Longevity.Technology System users:</strong></p>
<p>To check your risks for magnesium deficiency:</p>
<ol class="wp-block-list">
<li>Download the LT System app on your Android or Apple smartphone.</li>
<li>Open the LT System app and select ‘DNA Results’</li>
<li>Under ‘Vitamins,’ scroll down and find ‘Magnesium Deficiency’</li>
<li>Now, scroll down to find your results and recommendations.</li>
</ol>
<p><strong>Not a user yet?</strong></p>
<p>That’s OK, you can sign up for your Epigenetic & DNA test <a href="https://longevity.technology/store/epigenetic-dna-test-landing-page/?utm_source=lifestyle&utm_medium=blogs" target="_blank" rel="noreferrer noopener">here</a>.</p>
<hr class="wp-block-separator has-alpha-channel-opacity is-style-wide">
<p>Did you know that nearly half of the U.S. population consumes less than the required amount of magnesium from food [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/" target="_blank" rel="noreferrer noopener">1</a>]? This essential mineral is involved in over 300 biochemical reactions in the body, impacting nerve function and muscle contraction.</p>
<p>Yet, magnesium deficiency remains one of the most overlooked health issues, subtly undermining daily vitality and well-being. </p>
<p><a href="https://longevity.technology/store/product/epigenetics-dna-test/?utm_source=lifestyle&utm_medium=blogs">Epigenetic & DNA testing</a>, like the one offered by Longevity.Technology, provides advanced insights into your magnesium levels, helping to uncover deficiencies that traditional blood tests might miss. </p>
<p>Understanding the implications of insufficient magnesium is the first step toward optimizing your health. Let’s explore how lacking this critical nutrient can impact your life.</p>
<h2 class="wp-block-heading" id="h-what-happens-when-your-body-is-low-in-magnesium"><strong>What happens when your body is low in magnesium?</strong></h2>
<p><a href="https://longevity.technology/lifestyle/magnesium-deficiency-9-warning-signs-to-know-if-youre-at-risk/" target="_blank" rel="noreferrer noopener">Magnesium deficiency</a> subtly disrupts bodily functions, often unnoticed until more severe symptoms appear. Recognizing its impact is crucial for maintaining both immediate and long-term health. Here’s how low magnesium levels affect your body:</p>
<h3 class="wp-block-heading" id="h-muscle-and-nerve-function"><strong>Muscle and nerve function</strong></h3>
<ul class="wp-block-list">
<li><strong>Spasms and cramps:</strong> Low magnesium can lead to frequent muscle spasms [<a href="https://www.mcgill.ca/oss/article/health/magnesium" target="_blank" rel="noreferrer noopener">2</a>], including involuntary eye twitches and painful nocturnal leg cramps.<br></li>
<li><strong>Heart rhythm:</strong> Magnesium is essential for a healthy heart rhythm. Insufficient levels may cause palpitations or an irregular heartbeat, which can pose long-term risks.</li>
</ul>
<h3 class="wp-block-heading" id="h-energy-production"><strong>Energy production</strong></h3>
<ul class="wp-block-list">
<li><strong>Persistent fatigue:</strong> Even with adequate rest, a deficiency might leave you feeling constantly tired [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255271/" target="_blank" rel="noreferrer noopener">3</a>], as magnesium is vital for energy production at the cellular level.</li>
</ul>
<h3 class="wp-block-heading" id="h-mental-health"><strong>Mental health</strong></h3>
<ul class="wp-block-list">
<li><strong>Mood and anxiety:</strong> Magnesium aids brain function and regulates neurotransmitters, which affect mood. Deficiency may lead to increased irritability and anxiety.</li>
</ul>
<p>Recognizing these signs and understanding magnesium’s widespread role can help highlight its importance in daily health and overall vitality.</p>
<h2 class="wp-block-heading" id="h-are-you-experiencing-these-signs-of-magnesium-deficiency"><strong>Are you experiencing these signs of magnesium deficiency?</strong></h2>
<p>These symptoms, particularly when combined, suggest that your body’s magnesium levels might be critically low. Addressing these signs early by consulting a healthcare professional can help you restore balance and maintain your health.</p>
<h3 class="wp-block-heading" id="h-early-symptoms"><strong>Early symptoms</strong></h3>
<ol class="wp-block-list">
<li>Fatigue – A general sense of tiredness may be one of the first signs of low magnesium.<br></li>
<li>Muscle weakness or spasms – You might experience general weakness, sudden muscle cramps, or twitches.<br></li>
<li>Nausea – This can often accompany a deficiency, sometimes progressing to vomiting if not addressed.</li>
</ol>
<h3 class="wp-block-heading" id="h-severe-deficiency-indicators"><strong>Severe deficiency indicators</strong></h3>
<ol class="wp-block-list">
<li>Numbness and tingling – As deficiency worsens, you may feel numbness or tingling in your limbs.<br></li>
<li>Personality changes – Severe magnesium deficiency can lead to noticeable changes in mood and behavior, such as increased anxiety and depressive symptoms [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352515/" target="_blank" rel="noreferrer noopener">4</a>].<br></li>
<li>Heart arrhythmias – One of the most critical signs, irregular heartbeats or palpitations, indicate a significant magnesium deficiency that requires immediate attention.</li>
</ol>
<figure class="wp-block-image size-large"><img decoding="async" width="1200" height="800" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/biofeedback-training-session-2023-11-27-05-33-06-utc-microgen-envato-1200x800.jpg" alt="heart arrhythmias" class="wp-image-81575"><figcaption class="wp-element-caption">Photograph: microgen/Envato</figcaption></figure>
<h2 class="wp-block-heading" id="h-what-are-the-long-term-consequences-of-magnesium-deficiency"><strong>What are the long-term consequences of magnesium deficiency?</strong></h2>
<p>Understanding the long-term consequences of not having enough magnesium underscores the necessity of maintaining adequate levels for your health. Here’s what prolonged deficiency could lead to:</p>
<h3 class="wp-block-heading" id="h-bone-health-deterioration"><strong>Bone health deterioration</strong></h3>
<p>Magnesium is crucial for bone formation and influences the activities of cells responsible for building bones. A deficiency can result in weaker bones, increasing the risk of osteoporosis [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313472/" target="_blank" rel="noreferrer noopener">5</a>].</p>
<h3 class="wp-block-heading" id="h-cardiovascular-diseases"><strong>Cardiovascular diseases</strong></h3>
<p>Chronic low magnesium levels are linked to higher risks of hypertension and heart disease [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222666/" target="_blank" rel="noreferrer noopener">6</a>]. This mineral helps regulate blood pressure, and its insufficiency can lead to cardiovascular complications.</p>
<h3 class="wp-block-heading" id="h-metabolic-syndrome"><strong>Metabolic syndrome</strong></h3>
<p>Insufficient magnesium can influence glucose and insulin metabolism, contributing to type 2 diabetes and <a href="https://longevity.technology/lifestyle/is-stress-to-blame-for-metabolic-syndrome-new-study-sheds-light/" target="_blank" rel="noreferrer noopener">metabolic syndrome</a> [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470576/" target="_blank" rel="noreferrer noopener">7</a>]. Maintaining adequate magnesium levels is vital for metabolic health.</p>
<h3 class="wp-block-heading" id="h-mental-health-issues"><strong>Mental health issues</strong></h3>
<p>Long-term deficiency may exacerbate mental health problems such as depression and anxiety. Magnesium plays a protective role in the nervous system, and its lack can have significant neuropsychiatric effects [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352515/" target="_blank" rel="noreferrer noopener">4</a>].</p>
<h2 class="wp-block-heading" id="h-who-is-prone-to-magnesium-deficiency"><strong>Who is prone to magnesium deficiency?</strong></h2>
<p>Certain groups and lifestyle factors increase the risk of magnesium deficiency. Understanding who is most at risk can help in taking preventive measures. Here are the key risk factors:</p>
<h3 class="wp-block-heading" id="h-dietary-habits"><strong>Dietary habits</strong></h3>
<p>Individuals who consume insufficient green leafy vegetables, nuts, seeds, and whole grains are likelier to develop magnesium deficiency.</p>
<h3 class="wp-block-heading" id="h-health-conditions"><strong>Health conditions</strong></h3>
<ul class="wp-block-list">
<li><strong>Gastrointestinal diseases:</strong> Conditions like Crohn’s, celiac, and chronic diarrhea can impair magnesium absorption [<a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/" target="_blank" rel="noreferrer noopener">8</a>].<br></li>
<li><strong>Diabetes:</strong> People with type 2 diabetes often experience increased magnesium loss in urine.<br></li>
<li><strong>Alcohol dependence:</strong> Excessive alcohol consumption can lead to lower magnesium levels due to increased urinary excretion and decreased absorption [<a href="https://pubmed.ncbi.nlm.nih.gov/7836619/" target="_blank" rel="noreferrer noopener">9</a>].</li>
</ul>
<h3 class="wp-block-heading" id="h-age-related-factors"><strong>Age-related factors</strong></h3>
<p>Aging can reduce magnesium absorption and increase the risk of deficiency due to dietary restrictions or changes in digestion [<a href="https://www.news-medical.net/news/20240213/Magnesiums-pivotal-role-in-slowing-agings-impact.aspx" target="_blank" rel="noreferrer noopener">10</a>].</p>
<h2 class="wp-block-heading" id="h-how-do-you-know-if-you-are-magnesium-deficient"><strong>How do you know if you are magnesium deficient?</strong></h2>
<p>Identifying magnesium deficiency accurately is key to addressing its myriad effects on health. Traditional methods primarily involve serum magnesium tests, measuring your blood’s magnesium level. </p>
<p>However, these tests can be misleading as only a small percentage of the body’s magnesium is stored in the blood, potentially overlooking cellular or bone deficiencies.</p>
<p>Innovative approaches like epigenetic and DNA testing offer a more comprehensive understanding. Longevity.Technology’s <a href="https://longevity.technology/store/product/epigenetics-dna-test/?utm_source=lifestyle&utm_medium=blogs">Epigenetic & DNA Test</a> goes beyond simple nutrient tracking to provide a detailed view of your mineral balance, including magnesium. </p>
<p>This test analyzes the impact of your lifestyle and genetic predispositions on your nutrient levels and overall health, offering a nuanced snapshot not just of what’s circulating in your bloodstream but also of how your cells are actually using these nutrients. </p>
<p>For those keen on a proactive approach to health management, this method stands out as a sophisticated tool for ensuring <a href="https://longevity.technology/lifestyle/what-is-the-optimal-daily-magnesium-dosage-for-women/" target="_blank" rel="noreferrer noopener">optimal magnesium levels</a> and preventing the long-term consequences of deficiency.</p>
<h2 class="wp-block-heading" id="h-how-can-you-correct-and-prevent-magnesium-deficiency"><strong>How can you correct and prevent magnesium deficiency?</strong></h2>
<p>Correcting magnesium deficiency is crucial for restoring health and preventing further complications, but the time can vary. </p>
<p>Generally, with consistent dietary changes and supplementation, initial improvements may be noticed within a few days, though restoring magnesium levels often takes several months.</p>
<p>To effectively manage and prevent low magnesium levels, consider the following strategies:</p>
<p>1. Increase intake of <a href="https://longevity.technology/lifestyle/10-food-sources-of-magnesium-you-should-eat/" target="_blank" rel="noreferrer noopener">magnesium-rich foods</a> such as leafy greens, nuts, seeds, and whole grains. These natural sources are beneficial for gradually increasing magnesium levels.</p>
<p>2. If dietary changes are insufficient, <a href="https://longevity.technology/lifestyle/7-side-effects-when-you-take-magnesium-supplements/" target="_blank" rel="noreferrer noopener">magnesium supplements</a> can be a direct method to boost levels. It’s important to choose an easily absorbed form, like <a href="https://longevity.technology/lifestyle/how-does-magnesium-glycinate-benefit-your-body-and-mind/" target="_blank" rel="noreferrer noopener">magnesium glycinate</a> or citrate.</p>
<p>3. Monitor your magnesium levels using tools like the Longevity.Technology <a href="https://longevity.technology/store/product/epigenetics-dna-test/?utm_source=lifestyle&utm_medium=blogs">Epigenetic & DNA Test</a>. These tests can help you better understand your body’s magnesium status and tailor your supplementation and dietary strategies more effectively.</p>
<p>4. Reducing alcohol consumption, quitting smoking, and managing stress are also vital, as these factors can affect magnesium retention and overall health.</p>
<figure class="wp-block-image size-large"><img decoding="async" width="1200" height="800" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/inscription-mg-and-healthy-food-as-source-natural-2023-11-27-05-10-44-utc-ratmaner-Envato-1200x800.jpg" alt="magnesium food sources" class="wp-image-81416"><figcaption class="wp-element-caption">Photograph: ratmaner/Envato</figcaption></figure>
<h2 class="wp-block-heading" id="h-can-you-live-with-low-magnesium"><strong>Can you live with low magnesium?</strong></h2>
<p>While it is technically possible to live with low magnesium, doing so can significantly impact your quality of life and lead to various health complications. </p>
<p>Understanding the potential risks and why proactive management is essential can help mitigate serious health issues.</p>
<h3 class="wp-block-heading" id="h-1-cardiovascular-health"><strong>1. Cardiovascular health</strong></h3>
<p>Chronic magnesium deficiency is linked to increased risks of hypertension and heart disease. Magnesium plays a critical role in heart function, helping to maintain normal heart rhythms and prevent arrhythmias.</p>
<h3 class="wp-block-heading" id="h-2-bone-integrity"><strong>2. Bone integrity</strong></h3>
<p>Magnesium is vital for bone health. It contributes to your bones’ physical structure, influencing osteoblast and osteoclast activities. Prolonged deficiency can weaken bones, increasing the risk of fractures and osteoporosis.</p>
<h3 class="wp-block-heading" id="h-3-mental-health-effects"><strong>3. Mental health effects</strong></h3>
<p>Low magnesium levels are often associated with neurological and psychological issues, including increased anxiety, depression, and overall mood disturbances. This is due to magnesium’s role in neurotransmitter regulation.</p>
<h3 class="wp-block-heading" id="h-4-metabolic-concerns"><strong>4. Metabolic concerns</strong></h3>
<p>Magnesium aids in the metabolism of carbohydrates and fats, influencing blood sugar levels and overall metabolic health. Deficiency can exacerbate or increase the <a href="https://longevity.technology/lifestyle/what-should-you-do-if-you-have-a-high-genetic-risk-for-type-2-diabetes/" target="_blank" rel="noreferrer noopener">risk of type 2 diabetes</a> and metabolic syndrome.</p>
<h2 class="wp-block-heading" id="h-enhance-your-magnesium-levels-with-the-epigenetic-amp-dna-test"><strong>Enhance your magnesium levels with the Epigenetic & DNA Test</strong></h2>
<p>Epigenetic and DNA testing are transforming how we understand and manage nutrient deficiencies, including magnesium. </p>
<p>These tests provide a more comprehensive view than traditional blood tests, which only measure immediate levels and often miss cellular deficiencies.</p>
<p>By analyzing DNA and epigenetic markers, these tests can reveal how your body processes and utilizes magnesium on a genetic level. </p>
<p>This insight allows for personalized nutrition and supplementation strategies tailored to your unique genetic makeup. </p>
<p>For example, if your DNA suggests a higher risk of magnesium deficiency, you might need to adjust your diet or supplement regimen accordingly.</p>
<p>The <a href="https://longevity.technology/store/product/epigenetics-dna-test/?utm_source=lifestyle&utm_medium=blogs">Epigenetic & DNA Test</a> offers a cutting-edge approach by identifying potential genetic predispositions and monitoring how lifestyle changes, like diet and stress management, impact your magnesium levels over time. </p>
<p>This proactive approach helps ensure that your body maintains optimal magnesium levels, enhancing overall health and preventing long-term complications associated with deficiency.</p>
<h2 class="wp-block-heading"><strong>Closing thoughts</strong></h2>
<p>Magnesium is pivotal in maintaining optimal health, yet its deficiency often goes unnoticed until significant health issues arise. Understanding the signs and consequences of low magnesium is crucial. </p>
<p>Advanced diagnostic tools, such as epigenetic and DNA testing, provide deeper insights into your magnesium status, enabling personalized and effective management strategies. </p>
<p>Embracing these methods, dietary adjustments, and lifestyle modifications can significantly enhance your well-being. </p>
<p>Take action today to ensure your magnesium levels are sufficient, safeguarding against the potential long-term health complications of deficiency.</p>
<h4 class="wp-block-heading"><strong>Are you experiencing signs of magnesium deficiency? Don’t wait for symptoms to worsen. Order the </strong><a href="https://longevity.technology/store/product/epigenetics-dna-test/?utm_source=lifestyle&utm_medium=blogs"><strong>Epigenetic & DNA Test</strong></a><strong> now and take the first step towards personalized health management and recovery.</strong></h4>
<h2 class="wp-block-heading"><strong>FAQs</strong></h2>
<h3 class="wp-block-heading"><strong>Can humans live without magnesium?</strong></h3>
<p>No, humans cannot live without magnesium; it’s essential for many bodily functions.</p>
<h3 class="wp-block-heading"><strong>Is it bad to take magnesium if you’re not deficient?</strong></h3>
<p>Taking magnesium when not deficient is generally safe but can lead to digestive issues if overused.</p>
<h3 class="wp-block-heading"><strong>How does low magnesium affect the brain?</strong></h3>
<p>Low magnesium can impair brain function, leading to symptoms like confusion, irritability, and reduced cognitive ability.</p>
<h3 class="wp-block-heading"><strong>Can low magnesium cause overthinking?</strong></h3>
<p>Low magnesium may contribute to psychological distress and symptoms like overthinking due to its role in regulating neurotransmitters.</p>
<p>[1] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/</a><br>[2] <a href="https://www.mcgill.ca/oss/article/health/magnesium" target="_blank" rel="noreferrer noopener">https://www.mcgill.ca/oss/article/health/magnesium</a><br>[3] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255271/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255271/</a><br>[4] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352515/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352515/</a><br>[5] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313472/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313472/</a><br>[6] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222666/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222666/</a><br>[7] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470576/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470576/</a><br>[8] <a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/" target="_blank" rel="noreferrer noopener">https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/</a><br>[9] <a href="https://pubmed.ncbi.nlm.nih.gov/7836619/" target="_blank" rel="noreferrer noopener">https://pubmed.ncbi.nlm.nih.gov/7836619/</a><br>[10] <a href="https://www.news-medical.net/news/20240213/Magnesiums-pivotal-role-in-slowing-agings-impact.aspx" target="_blank" rel="noreferrer noopener">https://www.news-medical.net/news/20240213/Magnesiums-pivotal-role-in-slowing-agings-impact.aspx</a></p>
<h6 class="wp-block-heading" id="h-photograph-ratmaner-envato">Photograph: ratmaner/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/how-does-magnesium-deficiency-affect-your-daily-life/">How does magnesium deficiency affect your daily life?</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
How ergothioneine protects your brain from aging and stress
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/young-woman-taking-vitamin-supplements-2023-11-27-05-01-54-utc-seventyfourimages-Envato.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="How ergothioneine protects your brain from aging and stress" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="(max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px">
<p><a href="https://longevity.technology/lifestyle/ergothioneine-benefits-side-effects-uses-foods-dosage/" target="_blank" rel="noreferrer noopener">Ergothioneine</a> is not a common household name yet, but its potential benefits make it worth knowing. It’s an amino acid with strong antioxidant properties, naturally present in mushrooms, red and black beans, and oat bran. </p>
<p>Recent studies highlight its role in protecting brain cells from damage, helping combat aging and stress.</p>
<p>Incorporating ergothioneine into your diet can be a proactive step towards better brain health. Whether through natural food sources or supplements, this nutrient offers a promising way to support cognitive function and resilience against stress. </p>
<p>As we explore its <a href="https://longevity.technology/lifestyle/7-health-benefits-of-ergothioneine/" target="_blank" rel="noreferrer noopener">benefits, ergothioneine</a> might become a staple in your brain health regimen.</p>
<h2 class="wp-block-heading" id="h-what-happens-to-our-brains-as-we-age"><strong>What happens to our brains as we age?</strong></h2>
<p>Aging is a natural part of life, but its effects on the brain can be particularly challenging. As we grow older, our cognitive abilities often decline, and many face issues such as <a href="https://longevity.technology/lifestyle/can-a-high-fat-diet-accelerate-memory-loss-or-is-it-just-aging/" target="_blank" rel="noreferrer noopener">memory loss</a> or <a href="https://longevity.technology/lifestyle/morning-person-or-night-owl-uk-biobank-study-shows-whos-sharper/" target="_blank" rel="noreferrer noopener">reduced mental sharpness</a> [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906299/" target="_blank" rel="noreferrer noopener">1</a>]. </p>
<p>Understanding what happens to our <a href="https://longevity.technology/lifestyle/secrets-of-middle-age-brain-health-what-researchers-found-out/" target="_blank" rel="noreferrer noopener">brains as we age</a> can help us take proactive steps to maintain cognitive health.</p>
<h3 class="wp-block-heading" id="h-cognitive-decline-and-memory-loss"><strong>Cognitive decline and memory loss</strong></h3>
<p>Aging often brings cognitive decline and memory loss. Tasks may take longer, and names or items are harder to recall. These changes are common and usually mild, but persistent memory issues could indicate <a href="https://longevity.technology/lifestyle/mothers-role-in-alzheimers-new-study-highlights-genetic-impact/" target="_blank" rel="noreferrer noopener">serious conditions like Alzheimer’s</a>. </p>
<p>Maintaining brain health through a balanced diet, regular exercise, and mental stimulation can help mitigate these effects.</p>
<h3 class="wp-block-heading" id="h-neurodegenerative-diseases"><strong>Neurodegenerative diseases</strong></h3>
<p>Aging increases the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s. Alzheimer’s affects memory and cognitive functions, while Parkinson’s impacts movement and balance [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519729/" target="_blank" rel="noreferrer noopener">2</a>]. These diseases result from the progressive loss of neurons. </p>
<p>Maintaining brain health through diet, exercise, and mental activities can help reduce the risk and slow the progression of these conditions.</p>
<h3 class="wp-block-heading" id="h-the-role-of-oxidative-stress"><strong>The role of oxidative stress</strong></h3>
<p>Oxidative stress occurs when an imbalance between free radicals and antioxidants leads to cell damage. </p>
<p>The brain, highly susceptible due to its oxygen use and lipid content, suffers as oxidative <a href="https://longevity.technology/lifestyle/stress-takes-a-toll-study-reveals-how-life-events-accelerate-aging-in-adolescents/" target="_blank" rel="noreferrer noopener">stress accelerates aging</a> and contributes to diseases like Alzheimer’s. Antioxidants help neutralize free radicals, protecting brain health and slowing aging.</p>
<figure class="wp-block-image size-large"><img decoding="async" width="1200" height="800" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/old-women-have-dizziness-and-headache-due-to-stres-2023-11-27-05-04-13-utc-JR-50-Envato-1200x800.jpg" alt="role of oxidative stress" class="wp-image-81411"><figcaption class="wp-element-caption">Photograph: JR-50/Envato</figcaption></figure>
<h2 class="wp-block-heading" id="h-what-are-the-benefits-of-ergothioneine-supplements"><strong>What are the benefits of ergothioneine supplements?</strong></h2>
<p>Ergothioneine, a potent antioxidant found naturally in foods like mushrooms, beans, and oat bran, has gained attention for its remarkable health benefits. This powerful amino acid offers a range of advantages, particularly in protecting and enhancing brain health. </p>
<p>Let’s explore the benefits of ergothioneine supplementation in a way that’s both informative and easy to understand:</p>
<h3 class="wp-block-heading" id="h-powerful-antioxidant-properties"><strong>Powerful antioxidant properties</strong></h3>
<p>This amino acid neutralizes free radicals, unstable molecules that cause cellular damage and contribute to aging and disease. By <a href="https://longevity.technology/lifestyle/how-can-you-reduce-and-prevent-oxidative-stress-in-your-body/" target="_blank" rel="noreferrer noopener">combating oxidative stress</a>, ergothioneine protects cells throughout the body, including the brain, heart, and <a href="https://longevity.technology/lifestyle/ergothioneine-in-skincare-the-ultimate-anti-aging-powerhouse/" target="_blank" rel="noreferrer noopener">skin</a>.</p>
<p>Its antioxidant capacity is particularly beneficial for the brain, which is highly susceptible to oxidative damage due to its high <a href="https://longevity.technology/lifestyle/how-to-optimize-oxygen-usage-during-exercise-for-maximum-benefit/" target="_blank" rel="noreferrer noopener">oxygen consumption</a>. Ergothioneine helps <a href="https://longevity.technology/lifestyle/primeadine-gf-spermidine-review-can-it-really-boost-your-cellular-health/" target="_blank" rel="noreferrer noopener">maintain cellular health</a>, reduce inflammation, and prevent damage from environmental toxins and stress [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971627/" target="_blank" rel="noreferrer noopener">3</a>]. </p>
<p>Incorporating foods rich in ergothioneine, such as mushrooms, beans, and oat bran, or supplements can significantly enhance your body’s defense against oxidative stress, <a href="https://longevity.technology/lifestyle/why-is-ergothioneine-the-so-called-longevity-vitamin/" target="_blank" rel="noreferrer noopener">promoting overall health and longevity</a>.</p>
<h3 class="wp-block-heading" id="h-neuroprotection"><strong>Neuroprotection</strong></h3>
<p>Ergothioneine offers crucial neuroprotection, safeguarding brain health through its powerful antioxidant and anti-inflammatory properties. It protects neurons from oxidative damage, essential for maintaining cognitive function and preventing neurodegenerative diseases like Alzheimer’s and Parkinson’s.</p>
<p><strong>Key benefits include</strong>:</p>
<ul class="wp-block-list">
<li>Minimizes chronic <a href="https://longevity.technology/lifestyle/new-study-reveals-inflammation-in-20s-determines-cognitive-health-in-late-40s/" target="_blank" rel="noreferrer noopener">brain inflammation linked to cognitive decline</a>.</li>
<li>Shields brain cells from damage, ensuring optimal function.</li>
<li>Promotes the growth of new neurons, aiding learning and memory.</li>
</ul>
<h3 class="wp-block-heading" id="h-enhances-cognitive-function"><strong>Enhances cognitive function</strong></h3>
<p>Ergothioneine significantly enhances cognitive function through its potent antioxidant and neuroprotective effects. Regular supplementation can lead to noticeable improvements in various cognitive areas:</p>
<ul class="wp-block-list">
<li>It protects the hippocampus, crucial for forming short-term and long-term memories.</li>
<li>Reduces oxidative stress and inflammation, enhancing concentration and mental clarity.</li>
<li>Supports neurogenesis, aiding the brain’s ability to process and retain new information.</li>
</ul>
<p>These benefits make ergothioneine a <a href="https://longevity.technology/lifestyle/avocado-nutrients-and-brain-health-how-it-enhances-cognition/" target="_blank" rel="noreferrer noopener">valuable nutrient for people of all ages</a>, helping maintain sharp mental faculties and improving overall cognitive performance. </p>
<h3 class="wp-block-heading" id="h-stress-reduction"><strong>Stress reduction</strong></h3>
<p>Ergothioneine helps reduce the harmful effects of stress on the brain [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221166/" target="_blank" rel="noreferrer noopener">4</a>], promoting mental well-being and resilience. It offers several stress-reducing benefits:</p>
<ul class="wp-block-list">
<li>Balances stress hormones like cortisol, which, in excess, can harm the brain.</li>
<li>Reduces oxidative stress and inflammation, leading to better mood and reduced anxiety.</li>
<li>Shields brain cells from damage caused by chronic stress, supporting overall cognitive function.</li>
</ul>
<p>Incorporating <a href="https://longevity.technology/lifestyle/5-ergothioneine-packed-foods-for-your-anti-aging-diet/" target="_blank" rel="noreferrer noopener">ergothioneine-rich foods</a> such as mushrooms, beans, and oat bran, or taking supplements can help you maintain a healthier brain and enhance your ability to cope with everyday stressors.</p>
<h3 class="wp-block-heading" id="h-combating-oxidative-stress-with-antioxidants"><strong>Combating oxidative stress with antioxidants</strong></h3>
<p>Antioxidants are crucial in combating oxidative stress, which accelerates brain aging and contributes to diseases like Alzheimer’s. </p>
<p>By neutralizing free radicals, antioxidants protect brain cells from damage. A <a href="https://longevity.technology/lifestyle/groundbreaking-study-shows-antioxidants-could-reverse-effects-of-aging/" target="_blank" rel="noreferrer noopener">diet rich in antioxidants</a> supports brain health. Key sources include:</p>
<ul class="wp-block-list">
<li>Blueberries, strawberries</li>
<li>Walnuts, almonds</li>
<li>Spinach, kale</li>
</ul>
<h2 class="wp-block-heading" id="h-where-can-you-get-ergothioneine"><strong>Where can you get ergothioneine?</strong></h2>
<p>Adding ergothioneine to your daily routine is easier than you might think. This powerful antioxidant, known for its benefits for the brain and body, can be found in various foods and supplements [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681161/" target="_blank" rel="noreferrer noopener">5</a>]. </p>
<p>Here’s how you can seamlessly incorporate ergothioneine into your diet and lifestyle:</p>
<h3 class="wp-block-heading" id="h-food-sources-of-ergothioneine"><strong>Food sources of ergothioneine</strong></h3>
<p>Ergothioneine can be easily added to your diet through various natural foods. Here are some rich sources to consider:</p>
<ul class="wp-block-list">
<li><strong>Mushrooms</strong>: Particularly shiitake, oyster, and king bolete mushrooms</li>
<li><strong>Beans</strong>: Kidney beans, black beans, and red beans</li>
<li><strong>Oat bran</strong>: This versatile ingredient can be incorporated into your breakfast routine by adding it to oatmeal, smoothies, or baking it into muffins and breads.</li>
</ul>
<p>Including these foods in your meals can help you naturally boost your ergothioneine intake, supporting brain health and overall wellness. </p>
<h3 class="wp-block-heading" id="h-incorporating-ergothioneine-into-meals"><strong>Incorporating ergothioneine into meals</strong></h3>
<p>Incorporating ergothioneine into your meals is simple and delicious. Here’s how to easily include this powerful antioxidant in your diet:</p>
<h4 class="wp-block-heading" id="h-breakfast"><strong>Breakfast</strong></h4>
<p>Start your day with a bowl of oatmeal topped with oat bran, fresh berries, and a sprinkle of nuts. This combination boosts your ergothioneine intake while providing fiber and antioxidants.</p>
<h4 class="wp-block-heading" id="h-lunch"><strong>Lunch</strong></h4>
<p>A hearty mushroom and bean salad makes an excellent lunch. Mix mushrooms with black beans, leafy greens, and a light vinaigrette for a nutrient-packed meal.</p>
<h4 class="wp-block-heading" id="h-dinner"><strong>Dinner</strong></h4>
<p>Enhance your dinner with mushrooms added to your favorite pasta, stir-fry, or risotto. Pair mushrooms with other vegetables and lean proteins for a balanced, ergothioneine-rich dish.</p>
<h4 class="wp-block-heading" id="h-snacks"><strong>Snacks</strong></h4>
<p>A handful of mixed nuts with dried mushrooms is a convenient, ergothioneine-rich snack. You can also make bean-based dips like hummus or black bean dip to enjoy with veggie sticks or whole-grain crackers.</p>
<h3 class="wp-block-heading" id="h-supplement-options"><strong>Supplement options</strong></h3>
<p>Supplements offer a convenient alternative for those who find it challenging to get enough ergothioneine from food alone. Ergothioneine supplements come in various forms, including capsules and powders. Here’s how to incorporate them into your routine:</p>
<ul class="wp-block-list">
<li><strong>Capsules</strong>: To ensure consistent intake, take a daily ergothioneine capsule with your morning vitamins. Choose high-quality supplements from reputable brands for optimal benefits.</li>
<li><strong>Powders</strong>: Mix ergothioneine powder into smoothies, juices, or water. This option is perfect for those who prefer not to take pills and can be easily added to your favorite drinks.</li>
</ul>
<p>These supplements are reliable for boosting your ergothioneine levels, supporting brain health and overall well-being.</p>
<figure class="wp-block-image size-full"><img decoding="async" width="1200" height="800" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/capsule-2023-11-27-05-14-07-utc-nodar77-Envato.jpg" alt="supplement options" class="wp-image-81410"><figcaption class="wp-element-caption">Photograph: nodar77/Envato</figcaption></figure>
<h3 class="wp-block-heading" id="h-tips-for-consistent-intake"><strong>Tips for consistent intake</strong></h3>
<p>Maintaining a consistent intake of ergothioneine is key to reaping its benefits. Here are some practical tips:</p>
<ul class="wp-block-list">
<li>Plan meals to regularly include ergothioneine-rich foods like mushrooms, beans, and oat bran. Batch cooking and meal prepping ensure you always have healthy options available.</li>
<li>Keep your diet interesting by rotating various recipes that feature ergothioneine-rich ingredients. This prevents monotony and ensures a diverse nutrient intake.</li>
<li>If you opt for this route, use smartphone reminders or notes to remember your ergothioneine supplement. Consistency is easier with daily prompts.</li>
<li>Incorporate ergothioneine supplements into your routine, such as taking them with morning vitamins or blending powder into your breakfast smoothie [<a href="https://www.webmd.com/vitamins/ai/ingredientmono-1183/ergothioneine" target="_blank" rel="noreferrer noopener">6</a>].</li>
</ul>
<p>These strategies help maintain regular ergothioneine intake for optimal health benefits.</p>
<h2 class="wp-block-heading"><strong>In closing</strong></h2>
<p>Adding ergothioneine to your daily routine can significantly boost your brain and overall health. This potent antioxidant offers numerous benefits, from protecting neurons to reducing inflammation and improving cognitive function. </p>
<p>Incorporating ergothioneine into your diet, whether through food sources or supplements, is a straightforward and effective way to enhance your well-being.</p>
<p>Explore the benefits of ergothioneine and make it a staple in your wellness routine. Share your experiences and recipes with friends and family to spread the word about this incredible nutrient. Together, we can all enjoy the health benefits of ergothioneine.</p>
<h2 class="wp-block-heading"><strong>FAQs</strong></h2>
<h3 class="wp-block-heading"><strong>How does ergothioneine benefit brain health?</strong></h3>
<p>Ergothioneine protects neurons from damage and reduces inflammation in the brain. This helps maintain cognitive function and may prevent neurodegenerative diseases.</p>
<h3 class="wp-block-heading"><strong>Which foods are rich in ergothioneine?</strong></h3>
<p>Mushrooms, especially shiitake and oyster varieties, are high in ergothioneine. Beans and oat bran also contain significant amounts.</p>
<h3 class="wp-block-heading"><strong>Can I take ergothioneine as a supplement?</strong></h3>
<p>Yes, ergothioneine is available in supplement form, including capsules and powders. These supplements can help you achieve consistent intake.</p>
<h3 class="wp-block-heading"><strong>Can ergothioneine slow down aging?</strong></h3>
<p>Ergothioneine’s antioxidant properties help protect cells from damage, which can slow the aging process. It also supports overall cellular health.</p>
<p>[1] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906299/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906299/</a><br>[2] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519729/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519729/</a><br>[3] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971627/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971627/</a><br>[4] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221166/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221166/</a><br>[5] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681161/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681161/</a><br>[6] <a href="https://www.webmd.com/vitamins/ai/ingredientmono-1183/ergothioneine" target="_blank" rel="noreferrer noopener">https://www.webmd.com/vitamins/ai/ingredientmono-1183/ergothioneine</a></p>
<h6 class="wp-block-heading" id="h-photograph-seventyfourimages-envato">Photograph: seventyfourimages/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/how-ergothioneine-protects-your-brain-from-aging-and-stress/">How ergothioneine protects your brain from aging and stress</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
Will the Paris Olympics 2024 become a dengue fever hotspot?
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/olympics-paris-france-summer-multi-colored-ri-2024-01-31-02-12-31-utc-Aleruana-Envato.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="Will the Paris Olympics 2024 become a dengue fever hotspot?" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>In July 2024, the <a href="https://www.occitanie.ars.sante.fr/" target="_blank" rel="noreferrer noopener">Agence régionale de santé d’Occitanie</a> reported the first autochthonous dengue infection of the year near Montpellier, marking the earliest in a season that experts fear could witness unprecedented outbreaks [<a href="https://www.umontpellier.fr/en/articles/jo-2024-surveillance-renforcee-pour-le-moustique-tigre-et-la-dengue" target="_blank" rel="noreferrer noopener">1</a>]. </p>
<p>As Paris gears up to host the Olympics in 2024, this troubling precedent raises alarms about the potential for the city to become a hotspot for dengue fever, a disease transmitted by the Aedes albopictus or tiger mosquito. </p>
<p>The confluence of a global sporting event and favorable breeding <a href="https://longevity.technology/lifestyle/buzz-off-mastering-the-art-of-mosquito-magnetism/" target="_blank" rel="noreferrer noopener">conditions for mosquitoes</a> could create a perfect storm for dengue proliferation.</p>
<h2 class="wp-block-heading" id="h-the-growing-threat-of-dengue-in-france"><strong>The growing threat of dengue in France</strong></h2>
<p>While more common in tropical regions, dengue fever has seen a northward expansion in Europe, facilitated by climate change and the increasing presence of the tiger mosquito in southern France. </p>
<p>Historically limited to warmer climates, these mosquitoes have established populations in over 71 French départements or counties, including Paris [<a href="https://www.pasteur.fr/en/research-journal/news/tiger-mosquito-france-71-departements-red-alert" target="_blank" rel="noreferrer noopener">2</a>]. </p>
<p>This geographical spread is significant because it brings the vector—and the viruses it carries—into closer contact with larger populations, increasing the risk of outbreaks.</p>
<p>The <a href="https://www.umontpellier.fr/en/" target="_blank" rel="noreferrer noopener">University of Montpellier</a>‘s report highlights that the tiger mosquito’s active season in France now extends from May to November, peaking during summer [<a href="https://www.umontpellier.fr/en/articles/jo-2024-surveillance-renforcee-pour-le-moustique-tigre-et-la-dengue" target="_blank" rel="noreferrer noopener">1</a>]. </p>
<p>This aligns dangerously with the timing of the <a href="https://olympics.com/en/paris-2024" target="_blank" rel="noreferrer noopener">Paris Olympics</a>, set for July to August 2024, potentially elevating the risk of dengue transmission to both participants and spectators.</p>
<h2 class="wp-block-heading" id="h-olympic-preparations-and-public-health-measures"><strong>Olympic preparations and public health measures</strong></h2>
<p>The French health authorities have increased surveillance and control activities in response to the dengue threat. They are running public education campaigns to raise awareness about preventing mosquito bites, eliminating standing water to <a href="https://longevity.technology/lifestyle/insect-free-oasis-expert-tips-to-keep-mosquitoes-away-from-your-patio/" target="_blank" rel="noreferrer noopener">prevent mosquito breeding</a>, and conducting targeted insecticide spraying [<a href="https://www.umontpellier.fr/en/articles/jo-2024-surveillance-renforcee-pour-le-moustique-tigre-et-la-dengue" target="_blank" rel="noreferrer noopener">1</a>]. </p>
<p>These efforts are part of a larger plan to manage mosquito populations and reduce disease transmission during the Olympics. </p>
<p>Experts emphasize the importance of proactive measures. <a href="https://fr.linkedin.com/in/yannick-simonin-48b36386" target="_blank" rel="noreferrer noopener">Dr. Yannick Simonin</a>, a virologist at the University of Montpellier, stresses that while the threat of dengue is real, current strategies and public cooperation can help reduce risks. </p>
<p>Community involvement in mosquito control practices, such as removing standing water and using mosquito repellent, is crucial in preventing outbreaks [<a href="https://www.umontpellier.fr/en/articles/jo-2024-surveillance-renforcee-pour-le-moustique-tigre-et-la-dengue" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>The effectiveness of preventive measures will rely on the weather conditions before and during the games. Warmer temperatures and rainfall could promote mosquito breeding, challenging control efforts. </p>
<p>Dr. Simonin also mentions that climate change affects unpredictable weather patterns, adding complexity to prevention strategies [<a href="https://www.umontpellier.fr/en/articles/jo-2024-surveillance-renforcee-pour-le-moustique-tigre-et-la-dengue" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>With the combined efforts of global and local health authorities, the hope is to keep dengue fever at bay, allowing everyone to focus on the spirit and competition of the Games.</p>
<p>[1] University de Montpelier. <a href="https://www.umontpellier.fr/en/articles/jo-2024-surveillance-renforcee-pour-le-moustique-tigre-et-la-dengue" target="_blank" rel="noreferrer noopener">Olympic Games 2024: Tiger mosquito and dengue fever surveillance stepped up</a><br>[2] Institut Pasteur. <a href="https://www.pasteur.fr/en/research-journal/news/tiger-mosquito-france-71-departements-red-alert" target="_blank" rel="noreferrer noopener">Tiger mosquito in France: 71 Departments on red alert</a></p>
<h6 class="wp-block-heading" id="h-photograph-aleruana-envato">Photograph: Aleruana/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/will-the-paris-olympics-2024-become-a-dengue-fever-hotspot/">Will the Paris Olympics 2024 become a dengue fever hotspot?</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
How do you know if you’re choosing the right weight loss drug for you?
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/medicine-for-weight-loss-2023-11-27-05-10-47-utc-stockfilmstudio-Envato.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="How do you know if you're choosing the right weight loss drug for you?" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>Did you know that 2 in 5 adults in the United States are <a href="https://longevity.technology/lifestyle/us-ranks-10th-most-obese-country-in-the-world-researchers/" target="_blank" rel="noreferrer noopener">affected by obesity</a>, and nearly 1 in 11 Americans have severe obesity [<a href="https://www.niddk.nih.gov/health-information/health-statistics/overweight-obesity" target="_blank" rel="noreferrer noopener">1</a>]? This statistic highlights the pressing need for effective weight loss solutions.</p>
<p>Weight loss medications, also known as anti-obesity drugs, are designed to help individuals lose weight when diet and exercise alone are insufficient. </p>
<p>These medications work in various ways: suppressing appetite, increasing feelings of fullness, or reducing fat absorption. </p>
<p>The US FDA has approved several medications for long-term weight management, including orlistat, liraglutide, phentermine-topiramate, naltrexone-bupropion, and semaglutide [<a href="https://jamanetwork.com/journals/jama/article-abstract/2300603" target="_blank" rel="noreferrer noopener">2</a>], [<a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2816062" target="_blank" rel="noreferrer noopener">3</a>], [<a href="https://www.niddk.nih.gov/health-information/weight-management/prescription-medications-treat-overweight-obesity" target="_blank" rel="noreferrer noopener">4</a>].</p>
<p>But how do you know if you’re choosing the right weight loss drug for you? Let’s explore the factors to consider, backed by research and expert insights.</p>
<h2 class="wp-block-heading" id="h-factors-to-consider-when-choosing-a-weight-loss-medication"><strong>Factors to consider when choosing a weight loss medication</strong></h2>
<h3 class="wp-block-heading" id="h-1-medical-history-and-health-conditions"><strong>1. Medical history and health conditions</strong></h3>
<p>Before you start taking weight loss medications, it is important to consider your medical history and any existing health conditions. </p>
<p>Some medications may not be suitable for individuals with certain conditions, such as heart disease, high blood pressure, or thyroid problems. </p>
<p>For instance, <a href="https://longevity.technology/lifestyle/how-do-weight-loss-drugs-like-ozempic-wegovy-mounjaro-and-others-get-their-names/" target="_blank" rel="noreferrer noopener">weight loss drugs</a> like phentermine-topiramate may increase heart rate and should be used with caution in individuals with cardiovascular issues [<a href="https://jamanetwork.com/journals/jama/article-abstract/2300603" target="_blank" rel="noreferrer noopener">2</a>].</p>
<h3 class="wp-block-heading" id="h-2-body-mass-index-bmi"><strong>2. Body Mass Index (BMI)</strong></h3>
<p>Weight loss medications are typically prescribed based on your BMI. Generally, you’re considered a candidate for weight loss drugs if your BMI is 30 or higher. </p>
<p>Those with a BMI between 27 and 30 may also be eligible if they have weight-related health conditions like type 2 diabetes or high blood pressure [<a href="https://www.niddk.nih.gov/health-information/weight-management/prescription-medications-treat-overweight-obesity" target="_blank" rel="noreferrer noopener">4</a>].</p>
<h3 class="wp-block-heading" id="h-3-effectiveness-and-expected-weight-loss"><strong>3. Effectiveness and expected weight loss</strong></h3>
<p>It’s important to have realistic expectations about the effectiveness of weight loss medications. On average, individuals can expect to lose about 5% to 10% of their starting weight with the help of these medications. </p>
<p>However, responses can vary, with some individuals losing more weight and others less. Medications like semaglutide have shown promising results, with average weight loss ranging from 8% to 15% within 12 to 18 months of treatment [<a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2816062" target="_blank" rel="noreferrer noopener">3</a>].</p>
<h3 class="wp-block-heading" id="h-4-potential-side-effects"><strong>4. Potential side effects</strong></h3>
<p>Like all medications, weight loss drugs come with potential side effects, which may include diarrhea, nausea, constipation, and bloating. These side effects often occur at the beginning of treatment and tend to lessen over time. </p>
<p>However, some medications may have more serious side effects, and it is essential to discuss these risks with your healthcare provider [<a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2816062" target="_blank" rel="noreferrer noopener">3</a>], [<a href="https://www.niddk.nih.gov/health-information/weight-management/prescription-medications-treat-overweight-obesity" target="_blank" rel="noreferrer noopener">4</a>].</p>
<h3 class="wp-block-heading" id="h-5-lifestyle-and-treatment-adherence"><strong>5. Lifestyle and treatment adherence</strong></h3>
<p>Weight loss medications are <a href="https://longevity.technology/lifestyle/experts-say-weight-loss-drugs-cant-combat-obesity-without-nutrition/" target="_blank" rel="noreferrer noopener">most effective with lifestyle modifications</a> like engaging in regular physical activities and adopting a balanced diet. Commitment to these lifestyle changes is crucial for achieving and maintaining weight loss. </p>
<p>Medications should be viewed as a tool to assist in weight loss, not as a standalone solution [<a href="https://jamanetwork.com/journals/jama/article-abstract/2300603" target="_blank" rel="noreferrer noopener">2</a>].</p>
<h2 class="wp-block-heading" id="h-critical-points-to-understand-about-weight-loss-drugs"><strong>Critical points to understand about weight loss drugs</strong></h2>
<p>It’s essential to have realistic expectations when starting a weight loss medication. The amount of weight loss is often less than many expect, with an average of about 5% to 10% of the starting weight [<a href="https://jamanetwork.com/journals/jama/article-abstract/2300603" target="_blank" rel="noreferrer noopener">2</a>].</p>
<p>Injectable weight-loss medications like liraglutide, <a href="https://longevity.technology/lifestyle/semaglutide-the-weight-loss-drug-that-could-add-years-to-your-life/" target="_blank" rel="noreferrer noopener">semaglutide</a>, and <a href="https://longevity.technology/lifestyle/tirzepatide-the-diabetes-drug-transforming-sleep-apnea-treatment/" target="_blank" rel="noreferrer noopener">tirzepatide</a> have been shown to lead to more significant weight loss than <a href="https://longevity.technology/lifestyle/how-does-oral-semaglutide-impact-diabetes-management/" target="_blank" rel="noreferrer noopener">oral medications</a> or lifestyle changes alone. </p>
<p>Research indicates an average weight loss of 8% to 15% within 12 to 18 months of starting an injectable medication [<a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2816062" target="_blank" rel="noreferrer noopener">3</a>].</p>
<p>It is important to have regular monitoring by a medical professional as this is essential to observe any potential side effects and to evaluate the medication’s effectiveness.</p>
<p>Weight loss medications should be used with caution, particularly for individuals with certain health conditions such as cardiovascular issues [<a href="https://www.niddk.nih.gov/health-information/weight-management/prescription-medications-treat-overweight-obesity" target="_blank" rel="noreferrer noopener">4</a>].</p>
<p>While weight loss medications can be effective in managing obesity, careful consideration of medical history, BMI, lifestyle, and potential side effects is necessary.</p>
<p>Remember to always seek advice from your physician to make a well-informed choice that aligns with your health and weight reduction objectives.</p>
<p>With the right approach and medical guidance, weight loss medications can help you achieve and maintain a healthier weight, improving your overall health and well-being.</p>
<p>[1] National Institute of Diabetes and Digestive and Kidney Diseases. <a href="https://www.niddk.nih.gov/health-information/health-statistics/overweight-obesity" target="_blank" rel="noreferrer noopener">Overweight & Obesity Statistics</a> <br>[2] JAMA Network. <a href="https://jamanetwork.com/journals/jama/article-abstract/2300603" target="_blank" rel="noreferrer noopener">Medications for Weight Loss: Indications and Usage<br></a>[3] JAMA Internal Medicine. <a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2816062" target="_blank" rel="noreferrer noopener">What Should I Know About Injectable Weight-Loss Medications?</a><br>[4] National Institute of Diabetes and Digestive and Kidney Diseases. <a href="https://www.niddk.nih.gov/health-information/weight-management/prescription-medications-treat-overweight-obesity" target="_blank" rel="noreferrer noopener">Prescription Medications to Treat Overweight & Obesity</a></p>
<h6 class="wp-block-heading" id="h-photograph-stockfilmstudio-envato">Photograph: stockfilmstudio/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/how-do-you-know-if-youre-choosing-the-right-weight-loss-drug-for-you/">How do you know if you’re choosing the right weight loss drug for you?</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
New Alzheimer’s disease biomarkers identified
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/New-Alzheimers-disease-biomarkers-identified.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="New Alzheimer's disease biomarkers identified" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>A recent study has uncovered new biomarkers for Alzheimer’s disease, offering hope for more precise diagnosis and <a href="https://longevity.technology/lifestyle/rapamycin-as-a-potential-treatment-for-alzheimers-disease/" target="_blank" rel="noreferrer noopener">potential treatment</a> [<a href="https://medicalxpress.com/news/2024-07-biomarkers-alzheimer-disease.html" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>The research, published in <em><a target="_blank" href="https://www.nature.com/articles/s41562-024-01924-6" rel="noreferrer noopener">Nature Human Behaviour</a></em>, identifies specific proteins and genetic markers associated with the disease’s progression. This breakthrough could significantly impact early diagnosis and personalized treatment strategies.</p>
<p>The study, led by researchers from the University of Oxford and the University of Edinburgh, analyzed blood samples from thousands of participants to identify biomarkers linked to Alzheimer’s. They discovered that elevated levels of certain proteins, such as neurogranin and tau, were present in individuals who developed Alzheimer’s disease [<a target="_blank" href="https://www.nature.com/articles/s41562-024-01924-6" rel="noreferrer noopener">2</a>].</p>
<p>Additionally, <a href="https://longevity.technology/lifestyle/mothers-role-in-alzheimers-new-study-highlights-genetic-impact/" target="_blank" rel="noreferrer noopener">specific genetic variations</a> were found to increase the risk of the disease, highlighting potential areas for targeted therapies that could revolutionize Alzheimer’s treatment.</p>
<p>These biomarkers could significantly enhance diagnostic accuracy and allow for <a href="https://longevity.technology/lifestyle/should-you-consider-genetic-testing-for-alzheimers-risk/" target="_blank" rel="noreferrer noopener">earlier intervention</a>, potentially <a href="https://longevity.technology/lifestyle/the-key-to-slowing-alzheimers-may-surprise-you-its-all-about-lifestyle/" target="_blank" rel="noreferrer noopener">slowing disease progression</a>. The findings also open up new avenues for research into treatments that could mitigate or even <a href="https://longevity.technology/lifestyle/what-is-osmotin-and-how-can-it-prevent-alzheimers/" target="_blank" rel="noreferrer noopener">prevent the onset of Alzheimer’s</a>, promising a brighter future in the fight against this disease [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869589/" target="_blank" rel="noreferrer noopener">3</a>].</p>
<p>This research represents a significant advancement in Alzheimer’s disease science, offering a clearer understanding of its underlying mechanisms and paving the way for future therapeutic developments.</p>
<p>[1] MedicalXpress. <a href="https://medicalxpress.com/news/2024-07-biomarkers-alzheimer-disease.html" target="_blank" rel="noreferrer noopener">Study identifies new biomarkers of Alzheimer’s disease</a><br>[2] Nature Human Behaviour. <a href="https://www.nature.com/articles/s41562-024-01924-6" target="_blank" rel="noreferrer noopener">Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease</a><br>[3] Biology. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869589/" target="_blank" rel="noreferrer noopener">Antioxidants in Alzheimer’s Disease: Current Therapeutic Significance and Future Prospects</a></p>
<p>The post <a href="https://longevity.technology/lifestyle/new-alzheimers-disease-biomarkers-identified/">New Alzheimer’s disease biomarkers identified</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
Exploring Senescence in Tendon Function
There were four groups of cells used in total: three of them were taken from young mice, with one group being exposed to radiation and another group being exposed to doxorubicin, both of which induce senescence. One group of young cells was not exposed to any senescence inducers, and the fourth group was from naturally aged mice. After confirming that doxorubicin and radiation induce senescence both in tendons and in tenocytes, the researchers examined how these cells functioned by placing them
Is Kim Kardashian longevity’s GPT moment? Not quite.
Season finale to The Kardashians sees the family get their biological age test results from TruDiagnostic. Guess what? They’re younger.
The Season 5 finale of Hulu series The Kardashians saw several members of the family discover their biological age. Having taken the TruAge test, which measures over 75 biomarkers related to aging and health, including telomere length, immune system age and impacts of lifestyle factors, the family found out their results and their paces of aging on a video c
Oisín lands $15m to advance genetic medicines targeting multiple age-related conditions
Citing rise in GLP-1 popularity, longevity biotech refocuses on developing muscle-building therapy to combat frailty.
Longevity drug developer Oisín Biotechnologies has announced the “first close” of its $15 million Series A financing round to advance its pipeline of genetic medicines designed to combat age-related diseases. The funds will be primarily used to progress the company’s therapies focused on eliminating unwanted fat cells and enhancing muscle mass to combat frailty.
The priori
ChromaDex introduces NAD+ test kit
ChromaDex partners with 1health to launch test kit leveraging dried blood spot assay tech, offering NAD+ level tracking for personalized care.
Los Angeles-based ChromaDex has unveiled its Niagen+ NAD+ Test Kit. This advanced diagnostic tool, available exclusively through healthcare practitioners, aims to enhance patient care by providing reliable, accurate measurement of blood NAD+ levels– a critical factor in cellular health and energy regeneration.
Longevity.Technology: NAD+ is a coenzy
Boost your health & wellbeing with 8 benefits of resveratrol
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/Happy-man-with-grapes.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="Boost your health & wellbeing with 8 benefits of resveratrol" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="(max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px">
<p><a href="https://longevity.technology/lifestyle/all-about-resveratrol/" target="_blank" rel="noreferrer noopener">Resveratrol</a> is a polyphenol, an antioxidant commonly found in the skin of red grapes, blueberries, and peanuts. It’s also present in <a href="https://longevity.technology/lifestyle/red-wine-and-longevity-what-you-need-to-know/" target="_blank" rel="noreferrer noopener">red wine</a>, so moderate wine consumption is often linked to health benefits. </p>
<p>This compound gained fame due to its potential to improve heart health, but its advantages extend far beyond that.</p>
<p>Incorporating resveratrol into your diet is simple. Enjoy a glass of red wine with dinner, snack on blueberries, or consider taking a <a href="https://longevity.technology/lifestyle/7-best-resveratrol-supplements-to-buy-in-2024/" target="_blank" rel="noreferrer noopener">high-quality resveratrol supplement</a>. These small changes can lead to significant improvements in your health and well-being.</p>
<h2 class="wp-block-heading" id="h-what-are-the-health-benefits-of-taking-resveratrol"><strong>What are the health benefits of taking resveratrol?</strong></h2>
<p><a href="https://longevity.technology/lifestyle/resveratrol-benefits-side-effects-foods-uses-dosage/" target="_blank" rel="noreferrer noopener">Resveratrol offers numerous health benefits</a>—from supporting heart health to promoting longevity.</p>
<h3 class="wp-block-heading" id="h-1-heart-health"><strong>1. Heart health</strong></h3>
<p>Resveratrol supports cardiovascular health in several crucial ways. It lowers blood pressure and cholesterol, improves blood flow, and lessens inflammation—all of which dramatically cut the risk of heart disease.</p>
<p>Resveratrol maintains arteries flexible and healthy by enhancing blood vessel function and reducing obstructions that might result in heart attacks or strokes [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/" target="_blank" rel="noreferrer noopener">1</a>]. </p>
<p>Studies have indicated that resveratrol’s antioxidant characteristics shield the heart by scavenging dangerous free radicals, supporting a robust cardiovascular system.</p>
<h3 class="wp-block-heading" id="h-2-anti-inflammatory-properties"><strong>2. Anti-inflammatory properties</strong></h3>
<p>Resveratrol’s anti-inflammatory properties make it a valuable addition to any health regimen. It works by inhibiting enzymes and molecules that cause inflammation, thereby reducing the risk of chronic inflammatory conditions like arthritis and certain cancers. </p>
<p>This powerful polyphenol can help manage symptoms of existing inflammatory diseases and prevent new issues from arising. </p>
<p>Resveratrol curbs inflammation, alleviating pain and discomfort while protecting against long-term damage linked to chronic inflammation. </p>
<h3 class="wp-block-heading" id="h-3-longevity-and-aging"><strong>3. Longevity and aging</strong></h3>
<p>It activates certain genes associated with longer lifespans and improved cellular health. This powerful compound mimics the effects of <a href="https://longevity.technology/lifestyle/how-does-calorie-restriction-boost-longevity/" target="_blank" rel="noreferrer noopener">calorie restriction, known for its lifespan-extending benefits</a>, without the need to drastically cut calories. </p>
<p>Resveratrol’s antioxidant and anti-inflammatory properties also protect against age-related diseases, ensuring better overall health as you age. </p>
<p>Including resveratrol in your diet or taking high-quality supplements can help enhance your quality of life and support a longer, healthier lifespan [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289612/" target="_blank" rel="noreferrer noopener">2</a>].</p>
<figure class="wp-block-image size-large"><img decoding="async" width="1200" height="798" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/white-haired-elderly-person-exercising-in-the-park-2023-11-27-05-31-57-utc-photobyphotoboy-Envato-1200x798.jpg" alt="woman wearing orange shirt running outdoors holding smartphone" class="wp-image-81402"><figcaption class="wp-element-caption">Photograph: photobyphotoboy/Envato</figcaption></figure>
<h3 class="wp-block-heading" id="h-4-antioxidant-power"><strong>4. Antioxidant power</strong></h3>
<p>Resveratrol fights oxidative stress, a condition caused by an imbalance between free radicals and antioxidants in the body. It safeguards cells by neutralizing free radicals, thereby preventing damage. This process helps to slow aging and lower the risk of chronic diseases.</p>
<p>This compound also helps maintain healthy skin, improves organ function, and supports overall cellular health. </p>
<p>Including foods rich in resveratrol in your diet can help shield your body from the harmful effects of oxidative stress, promoting a healthier and more vibrant life.</p>
<h3 class="wp-block-heading" id="h-5-brain-health"><strong>5. Brain health</strong></h3>
<p>Resveratrol supports brain health by enhancing cognitive function and protecting against neurodegenerative diseases like Alzheimer’s. This powerful compound improves blood flow to the brain, supports memory, and boosts overall mental performance. </p>
<p>Research shows that resveratrol can cross the blood-brain barrier, directly benefiting <a href="https://longevity.technology/lifestyle/exercise-found-to-reverse-brain-cell-aging-in-mice/" target="_blank" rel="noreferrer noopener">brain cells</a> and reducing the <a href="https://longevity.technology/lifestyle/10-year-european-study-finds-increased-cognitive-decline-in-14-countries-due-to-lifestyle/" target="_blank" rel="noreferrer noopener">risk of cognitive decline</a>. </p>
<p>Incorporating resveratrol into your diet can help maintain mental clarity, <a href="https://longevity.technology/lifestyle/7-must-try-brain-health-exercises-for-superior-mental-fitness/" target="_blank" rel="noreferrer noopener">protect your brain from age-related damage</a>, and promote long-term cognitive health.</p>
<h3 class="wp-block-heading" id="h-6-abnormal-cell-growth-prevention"><strong>6. Abnormal cell growth prevention</strong></h3>
<p>Resveratrol can slow the formation of aberrant cells and stop abnormal cells from spreading. It acts at various stages of cell development, including initiation, promotion, and progression, making it a valuable compound for maintaining cellular health. </p>
<p>By interfering with pathways that allow unhealthy cells to grow and spread, resveratrol provides a protective effect against several types of conditions. </p>
<h3 class="wp-block-heading" id="h-7-weight-management-and-blood-sugar-control"><strong>7. Weight management and blood sugar control</strong></h3>
<p>Resveratrol helps regulate blood sugar levels, making it beneficial for managing diabetes. It <a href="https://longevity.technology/lifestyle/7-effective-supplements-if-you-have-insulin-resistance/" target="_blank" rel="noreferrer noopener">enhances insulin sensitivity</a> and activates specific proteins that control glucose levels [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610395/" target="_blank" rel="noreferrer noopener">3</a>], which aids in maintaining stable blood sugar. This can reduce the risk of diabetes-related complications and <a href="https://longevity.technology/lifestyle/7-key-insights-into-how-rehit-optimizes-your-metabolic-health/" target="_blank" rel="noreferrer noopener">improve overall metabolic health</a>. </p>
<p>This compound also supports weight management by boosting metabolism and preventing fat accumulation. It activates the protein SIRT1, which helps the body <a href="https://longevity.technology/lifestyle/how-to-effectively-lose-body-fat-and-keep-it-off/" target="_blank" rel="noreferrer noopener">manage fat and improve energy</a> efficiency. This leads to increased fat burning and better weight control. </p>
<p>Additionally, resveratrol helps regulate hormones that influence appetite and fat storage, making it easier to maintain a healthy weight. </p>
<h3 class="wp-block-heading" id="h-8-tumor-inhibition"><strong>8. Tumor inhibition</strong></h3>
<p>Research suggests that resveratrol can inhibit the growth of abnormal cells and reduce the spread of tumors. It affects various stages of cell development, including initiation, promotion, and progression. This makes it a promising supplement for preventing abnormal cell growth. </p>
<p>Resveratrol protects against several conditions by interfering with the pathways that allow unhealthy cells to grow and spread.</p>
<h2 class="wp-block-heading" id="h-how-do-i-get-resveratrol-in-my-diet"><strong>How do I get resveratrol in my diet?</strong></h2>
<p>Adding resveratrol to your diet is easier and can bring various health benefits. Here are some simple and delicious ways to <a href="https://longevity.technology/lifestyle/5-resveratrol-rich-foods-to-supercharge-your-health/" target="_blank" rel="noreferrer noopener">boost your intake of resveratrol</a>:</p>
<ul class="wp-block-list">
<li><strong>Red wine: </strong>Enjoying a glass of <a href="https://longevity.technology/lifestyle/red-wine-and-healthy-food-choices-the-art-of-pairing/" target="_blank" rel="noreferrer noopener">red wine with dinner</a> can enhance your meal and provide health benefits. Remember, moderation is key—one glass per day for women and up to two for men.</li>
<li><strong>Grapes:</strong> They are versatile and can also be frozen for a refreshing treat or used as a natural sweetener in desserts. Regular <a href="https://longevity.technology/lifestyle/study-claims-eating-grapes-can-reduce-risk-of-skin-cancer-and-sunburn/" target="_blank" rel="noreferrer noopener">consumption of grapes</a> helps you easily incorporate resveratrol into your diet.</li>
<li><strong>Berries:</strong> Blueberries, cranberries, and mulberries are particularly rich in resveratrol. Enjoy them fresh, frozen, or dried by adding them to cereals, yogurt, or smoothies. They also make a great topping for pancakes and oatmeal or a quick snack mixed with nuts [<a href="https://www.healthline.com/nutrition/11-reasons-to-eat-berries" target="_blank" rel="noreferrer noopener">4</a>]. </li>
<li><strong>Peanuts: </strong>For a tasty treat, dip apple slices in peanut butter. Regular <a href="https://longevity.technology/lifestyle/brain-boosters-discover-the-brain-food-benefits-of-peanuts-and-peanut-butter/" target="_blank" rel="noreferrer noopener">consumption of peanuts</a> helps incorporate resveratrol into your diet.</li>
<li><strong>Dark chocolate: </strong>A delicious source of resveratrol [<a href="https://www.hcamidwest.com/healthy-living/blog/is-dark-chocolate-good-for-your-heart" target="_blank" rel="noreferrer noopener">5</a>]. Opt for chocolate with at least 70% cocoa content for the best benefits. Regularly enjoying <a href="https://longevity.technology/lifestyle/can-dark-chocolate-really-improve-your-health-specialist-says-yes/" target="_blank" rel="noreferrer noopener">dark chocolate</a> can help increase your resveratrol intake.</li>
</ul>
<h2 class="wp-block-heading" id="h-how-does-resveratrol-work-for-anti-aging"><strong>How does resveratrol work for anti-aging?</strong></h2>
<p>Resveratrol stands out due to its multifaceted approach to combating the aging process [<a href="https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2634/1316" target="_blank" rel="noreferrer noopener">6</a>]. It acts as a powerful antioxidant, enhances mitochondrial function, and regulates apoptosis, all of which are crucial for maintaining cellular health and longevity.</p>
<h3 class="wp-block-heading" id="h-antioxidant-role"><strong>Antioxidant role</strong></h3>
<p>Resveratrol’s primary protective effect against oxidative stress involves several mechanisms:</p>
<ul class="wp-block-list">
<li><strong>Lowering Reactive Oxygen Species (ROS) production:</strong> Resveratrol reduces the generation of ROS, which are harmful byproducts of cellular metabolism that can damage cells.</li>
<li><strong>Scavenging free radicals:</strong> It directly neutralizes free radicals, preventing them from causing cellular damage.</li>
<li><strong>Enhancing endogenous antioxidant enzymes:</strong> Resveratrol boosts the activity of enzymes, which is crucial for detoxifying harmful substances in the body.</li>
<li><strong>Increasing antioxidant compounds:</strong> It promotes the upregulation of genes associated with mitochondrial energy biogenesis, improving the cell’s ability to counteract oxidative stress.</li>
</ul>
<h3 class="wp-block-heading" id="h-enhancing-mitochondrial-function"><strong>Enhancing mitochondrial function</strong></h3>
<p>Dysfunctional mitochondria are a hallmark of aging. Resveratrol encourages mitochondrial biogenesis, reducing the movement of electrons per unit of mitochondria and, consequently, the production of ROS. </p>
<p>Resveratrol has been shown to:</p>
<ul class="wp-block-list">
<li><strong>Increase mitochondrial mass and DNA content:</strong> It supports the proliferation of mitochondria, enhancing their ability to produce energy efficiently.</li>
<li><strong>Enhance antioxidant defense mechanisms: </strong>By upregulating SOD in a SIRT1-dependent manner, resveratrol helps convert harmful superoxide radicals into less harmful substances.</li>
<li><strong>Promote mitophagy: </strong>Resveratrol induces the removal of damaged mitochondria, maintaining cellular homeostasis and replenishing healthy mitochondria.</li>
</ul>
<h3 class="wp-block-heading" id="h-regulating-apoptosis"><strong>Regulating apoptosis</strong></h3>
<p>Apoptosis, or programmed cell death, is crucial for maintaining cellular health. Resveratrol helps regulate apoptosis, removing damaged cells while preventing excessive cell death. It:</p>
<ul class="wp-block-list">
<li><strong>Preserves mitochondrial DNA:</strong> By reducing ROS, resveratrol protects mitochondrial DNA and supports ATP production.</li>
<li><strong>Inhibits apoptotic pathways:</strong> It prevents the release of cytochrome C and the activation of caspases, key components of the apoptotic pathway.</li>
</ul>
<figure class="wp-block-image size-full"><img decoding="async" width="1200" height="800" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/mitochondria.jpg" alt="regulating apoptosis" class="wp-image-81401"></figure>
<h2 class="wp-block-heading" id="h-new-resveratrol-s-potential-in-combating-alzheimer-s"><strong>New: Resveratrol’s potential in combating Alzheimer’s</strong></h2>
<p>A recent study highlights the promising role of resveratrol in combating Alzheimer’s disease through inflammatory suppression [<a href="https://www.news-medical.net/news/20240205/Resveratrol-can-combat-Alzheimers-via-inflammatory-suppression-study-shows.aspx" target="_blank" rel="noreferrer noopener">7</a>]. This research explores the mechanisms by which resveratrol can prevent and mitigate the effects of the disease.</p>
<p>Researchers have discovered some fascinating ways that resveratrol can help <a href="https://longevity.technology/lifestyle/what-is-osmotin-and-how-can-it-prevent-alzheimers/" target="_blank" rel="noreferrer noopener">fight Alzheimer’s disease</a>. Here are the key findings:</p>
<ol class="wp-block-list">
<li><strong>Blocking inflammation: </strong>Resveratrol helps reduce inflammation in the brain, which is a major factor in Alzheimer’s disease. It does this by stopping certain harmful substances from triggering inflammation. </li>
<li><strong>Boosting antioxidants:</strong> Our bodies have special proteins called enzymes that fight harmful molecules known as free radicals. Resveratrol increases the levels of these antioxidant enzymes. This boost helps protect brain cells from damage.</li>
<li><strong>Reducing harmful molecules:</strong> Resveratrol decreases the <a href="https://longevity.technology/lifestyle/7-ways-to-increase-nitric-oxide-naturally/" target="_blank" rel="noreferrer noopener">production of nitric oxide</a>, a molecule that can contribute to brain cell damage when present in high amounts. By <a href="https://longevity.technology/lifestyle/top-10-foods-to-boost-your-nitric-oxide-levels/" target="_blank" rel="noreferrer noopener">keeping nitric oxide levels in check</a>, resveratrol helps protect brain cells.</li>
<li><strong>Gene regulation: </strong>The study found that resveratrol can turn off certain genes that promote inflammation and oxidative stress. At the same time, it turns on genes that help protect the brain. This balancing act helps create a healthier environment for brain cells.</li>
</ol>
<p>Resveratrol works like a multitasking defender in the brain. It reduces inflammation, boosts protective enzymes, keeps harmful molecules in check, and helps regulate genes to maintain brain health. These combined actions make resveratrol a promising natural compound in the fight against Alzheimer’s disease.</p>
<h2 class="wp-block-heading"><strong>In closing</strong></h2>
<p>Resveratrol is a powerful compound with numerous health benefits, from supporting heart health to promoting longevity. </p>
<p>Incorporating resveratrol-rich foods like red wine, grapes, berries, peanuts, and dark chocolate into your diet is a simple and enjoyable way to boost your overall health and well-being. Supplements can also provide an additional boost, ensuring you get an adequate amount of this beneficial compound.</p>
<p>Taking steps to include resveratrol in your daily routine can significantly improve your health.</p>
<h2 class="wp-block-heading"><strong>FAQs</strong></h2>
<h3 class="wp-block-heading"><strong>How does resveratrol benefit heart health?</strong></h3>
<p>Resveratrol improves blood flow, reduces inflammation, and lowers blood pressure and cholesterol levels. These effects help reduce the risk of heart disease.</p>
<h3 class="wp-block-heading"><strong>Can resveratrol help with weight management?</strong></h3>
<p>Yes, resveratrol boosts metabolism and prevents fat accumulation. It activates proteins that help manage fat and improve energy efficiency.</p>
<h3 class="wp-block-heading"><strong>Is resveratrol safe to take as a supplement?</strong></h3>
<p>Generally, resveratrol supplements are safe when taken in recommended doses. Always consult with a healthcare provider before starting any new supplement.</p>
<h3 class="wp-block-heading"><strong>Which foods are rich in resveratrol?</strong></h3>
<p>Red grapes, blueberries, peanuts, and red wine are all rich sources of resveratrol. Dark chocolate also contains small amounts of this compound.</p>
<p>[1] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/</a><br>[2] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289612/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289612/</a><br>[3] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610395/" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610395/</a><br>[4] <a href="https://www.healthline.com/nutrition/11-reasons-to-eat-berries" target="_blank" rel="noreferrer noopener">https://www.healthline.com/nutrition/11-reasons-to-eat-berries</a><br>[5] <a href="https://www.hcamidwest.com/healthy-living/blog/is-dark-chocolate-good-for-your-heart" target="_blank" rel="noreferrer noopener">https://www.hcamidwest.com/healthy-living/blog/is-dark-chocolate-good-for-your-heart</a><br>[6] <a href="https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2634/1316" target="_blank" rel="noreferrer noopener">https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2634/1316</a> <br>[7] <a href="https://www.news-medical.net/news/20240205/Resveratrol-can-combat-Alzheimers-via-inflammatory-suppression-study-shows.aspx" target="_blank" rel="noreferrer noopener">https://www.news-medical.net/news/20240205/Resveratrol-can-combat-Alzheimers-via-inflammatory-suppression-study-shows.aspx</a></p>
<p></p>
<p>The post <a href="https://longevity.technology/lifestyle/boost-your-health-and-wellbeing-with-8-benefits-of-resveratrol/">Boost your health & wellbeing with 8 benefits of resveratrol</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
How to leverage the exercise effect on weight for maximum loss
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/06/obese-woman-working-out-in-fitness-club-2023-11-27-05-04-54-utcseventyfourimages-Envato-1200x800.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="How to leverage the exercise effect on weight for maximum loss" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="(max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px">
<p><strong>Longevity.Technology System users:</strong></p>
<p>To check your exercise effect on weight status:</p>
<ol class="wp-block-list">
<li>Download the LT System app on your <a href="https://play.google.com/store/apps/details?id=com.firstlongevity.app&pli=1">Android</a> or <a href="https://apps.apple.com/gb/app/lt-system/id6474242467">Apple</a> smartphone.</li>
<li>Open LT System app and select ‘DNA Results’</li>
<li>Under ‘Physical,’ scroll down and find ‘Exercise Effect On Weight’</li>
<li>Now, scroll down to find your results and recommendations.</li>
</ol>
<p><strong>Not a user yet?</strong></p>
<p>That’s OK; you can sign up for your Epigenetic & DNA test <a href="https://longevity.technology/store/epigenetic-dna-test-landing-page/?utm_source=lifestyle&utm_medium=blogs">here</a>.</p>
<hr class="wp-block-separator has-alpha-channel-opacity is-style-wide">
<p>Having <a href="https://longevity.technology/lifestyle/lifting-weights-but-not-losing-weight-here-are-8-reasons-why/" target="_blank" rel="noreferrer noopener">trouble losing weight</a> even with your greatest efforts? You’re not by yourself. Many people question what went wrong when they reached a brick wall in their weight loss efforts. The secret might lie in how you <a href="https://longevity.technology/lifestyle/5-ways-to-boost-your-power-to-weight-ratio-and-dominate-in-sports/" target="_blank" rel="noreferrer noopener">leverage exercise</a> to achieve maximum weight loss.</p>
<p>Research shows that combining specific exercise strategies with a balanced <a href="https://longevity.technology/lifestyle/ozempic-diet-plan-what-to-eat-for-maximum-weight-loss/" target="_blank" rel="noreferrer noopener">diet can boost weight loss</a> results by up to 30%. </p>
<p>Imagine transforming your body and achieving your weight loss goals more effectively by understanding and applying some proven principles. </p>
<p>Each type of exercise plays a crucial role, from cardiovascular exercises like running and cycling to strength training and HIIT workouts. But it’s not just about the workouts; nutrition, hydration, and recovery are equally important.</p>
<h2 class="wp-block-heading" id="h-what-type-of-exercise-is-best-for-weight-loss"><strong>What type of exercise is best for weight loss?</strong></h2>
<p>Achieving maximum weight loss requires a balanced exercise routine targeting various fitness aspects [<a href="https://www.healthline.com/health/exercise-and-weight-loss" target="_blank" rel="noreferrer noopener">1</a>]. By being aware of the kinds of <a href="https://longevity.technology/lifestyle/weight-loss-workout-the-only-guide-youll-ever-need/" target="_blank" rel="noreferrer noopener">workouts that promote weight loss</a>, you can create a successful fitness program. </p>
<p>Let’s discuss the main exercise categories and how they might assist you in losing those excess weight.</p>
<h3 class="wp-block-heading" id="h-1-cardiovascular-exercises"><strong>1. Cardiovascular exercises</strong></h3>
<p>Cardiovascular workouts are vital to any weight loss program because they burn calories and strengthen the heart.</p>
<ul class="wp-block-list">
<li><strong>Running</strong>: An effective calorie burner that <a href="https://longevity.technology/lifestyle/rise-shine-and-run-how-morning-cardio-might-just-extend-your-life/" target="_blank" rel="noreferrer noopener">boosts cardiovascular health</a>. Whether you prefer outdoor trails or a treadmill, running is a versatile exercise that fits any schedule.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Cycling</strong>: Another excellent cardio workout. Cycling can be done <a href="https://longevity.technology/lifestyle/indoor-vs-outdoor-cycling-which-one-should-you-be-doing/" target="_blank" rel="noreferrer noopener">outdoors or indoors</a> on a stationary bike. It’s a <a href="https://longevity.technology/lifestyle/cycling-an-easy-and-restorative-activity-for-all-ages/" target="_blank" rel="noreferrer noopener">low-impact, easy exercise on the joints</a> while offering significant calorie-burning potential.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Swimming</strong>: Provides a full-body workout and burns a high number of calories. <a href="https://longevity.technology/lifestyle/swimming-types-benefits-importance-and-research/" target="_blank" rel="noreferrer noopener">Swimming</a> is gentle on the body, making it ideal for all fitness levels.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Jumping rope</strong>: A high-intensity workout that’s easy to do anywhere. Jumping rope helps burn calories quickly and improves coordination and cardiovascular fitness.</li>
</ul>
<p>Aim for at least 150 minutes of moderate-intensity cardio each week for optimal results.</p>
<h3 class="wp-block-heading" id="h-2-strength-training"><strong>2. Strength training</strong></h3>
<p><a href="https://longevity.technology/lifestyle/why-is-strength-training-important-for-womens-weight-loss/" target="_blank" rel="noreferrer noopener">Strength training</a> is vital for building muscle mass, which increases your resting metabolic rate, helping you burn more calories even at rest.</p>
<ul class="wp-block-list">
<li><strong>Weightlifting</strong>: Gaining muscle with free weights or weight machines. Concentrate on complex exercises like bench presses, <a href="https://longevity.technology/lifestyle/why-should-you-do-deadlifts-to-burn-belly-fat/" target="_blank" rel="noreferrer noopener">deadlifts</a>, and squats for optimum results. These workouts burn more calories since they work different muscle groups.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Resistance bands</strong>: Resistance bands are a great substitute for weights in many activities. They provide constant tension on muscles, which helps build strength and muscle tone [<a href="https://www.betterhealth.vic.gov.au/health/healthyliving/resistance-training-health-benefits" target="_blank" rel="noreferrer noopener">2</a>].</li>
</ul>
<ul class="wp-block-list">
<li><strong>Bodyweight exercises</strong>: Push-ups, pull-ups, squats, and lunges utilize your body weight for resistance. These exercises are ideal for <a href="https://longevity.technology/lifestyle/home-workouts-5-at-home-strength-training-exercises-to-try/" target="_blank" rel="noreferrer noopener">at-home workouts</a> or on-the-go because they are highly effective and portable. </li>
</ul>
<h3 class="wp-block-heading" id="h-3-high-intensity-interval-training-hiit"><strong>3. High-intensity interval training (HIIT)</strong></h3>
<p>An effective training technique is high-intensity interval training (HIIT), which alternates <a href="https://longevity.technology/lifestyle/moderate-vs-vigorous-exercise-which-is-better-for-brain-function/" target="_blank" rel="noreferrer noopener">short bursts of vigorous exercise</a> with <a href="https://longevity.technology/lifestyle/active-recovery-vs-rest-day-10-differences-to-know/" target="_blank" rel="noreferrer noopener">rest or low-intensity activity</a> intervals. This method keeps your metabolism boosted even after the workout and burns a large number of calories quickly.</p>
<ul class="wp-block-list">
<li><strong>Sprint intervals</strong>: Running, walking, and jogging in succession. You can perform this exercise on a treadmill, track, or surface level. It’s highly effective for burning calories and improving cardiovascular fitness.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Circuit training</strong>: Combines different exercises like burpees, jumping jacks, and mountain climbers in quick succession with minimal rest. This works for numerous muscle groups while maintaining an elevated heart rate and optimizing calorie burn.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Tabata</strong>: A <a href="https://longevity.technology/lifestyle/are-tabata-exercises-effective-for-weight-loss/" target="_blank" rel="noreferrer noopener">type of HIIT</a> in which you exercise vigorously for 20 seconds, rest for 10 seconds, then repeat the process for four minutes. <a href="https://longevity.technology/lifestyle/7-fat-burning-tabata-workout-exercises-you-can-do-anywher/" target="_blank" rel="noreferrer noopener">Tabata</a> is a quick and effective way to burn calories and improve endurance.</li>
</ul>
<p><a href="https://longevity.technology/lifestyle/5-quick-hiit-routines-for-people-who-hate-cardi/" target="_blank" rel="noreferrer noopener">HIIT workouts</a> are ideal for those with busy schedules, as they can be completed quickly while providing significant benefits for weight loss and overall fitness. Aim for at least two HIIT sessions per week for optimal results.</p>
<figure class="wp-block-image size-large"><img decoding="async" width="1200" height="800" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/running-on-tracks-2023-11-27-04-52-38-utc-lzf-Envato-1200x800.jpg" alt="woman running wearing workout clothes" class="wp-image-81394"><figcaption class="wp-element-caption">Photograph: lzf/Envato</figcaption></figure>
<h3 class="wp-block-heading" id="h-4-flexibility-and-balance-exercises"><strong>4. Flexibility and balance exercises</strong></h3>
<p>Flexibility and balance exercises are essential for overall fitness, helping to prevent injuries, <a href="https://longevity.technology/lifestyle/7-exercises-to-improve-bad-posture/" target="_blank" rel="noreferrer noopener">improve posture</a>, and <a href="https://longevity.technology/lifestyle/10-proven-ways-to-enhance-your-muscle-health/" target="_blank" rel="noreferrer noopener">enhance muscle function</a>. While not primarily for weight loss, these exercises support a well-rounded fitness routine.</p>
<ul class="wp-block-list">
<li><strong>Yoga</strong>: Enhances flexibility, strength, and mental well-being. Poses like downward dog, warrior, and tree pose to <a href="https://longevity.technology/lifestyle/10-stretching-exercises-for-beginners-and-the-not-so-flexible/" target="_blank" rel="noreferrer noopener">stretch and strengthen muscles</a>, improve balance, and reduce stress.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Pilates</strong>: Focuses on core strength, flexibility, and balance. Exercises like the hundred, leg circles and roll-ups target the core muscles, improve stability, and promote better posture. Pilates is gentle on the body yet highly effective for building strength and flexibility.</li>
</ul>
<ul class="wp-block-list">
<li><strong>Tai chi</strong>: A <a href="https://longevity.technology/lifestyle/6-low-impact-10-minute-workouts-designed-for-seniors/" target="_blank" rel="noreferrer noopener">low-impact exercise</a> that improves balance, flexibility, and mental focus. It is appropriate for all ages and fitness levels because it requires deep breathing and deliberate, gradual movements.</li>
</ul>
<p>By increasing muscle function and lowering the chance of injury, adding flexibility and <a href="https://longevity.technology/lifestyle/7-balance-exercises-you-can-do-at-home-without-any-equipment/" target="_blank" rel="noreferrer noopener">balancing exercises</a> to your regimen improves overall fitness and complements other types of training. Aim for at least one to two weekly sessions to maintain flexibility and balance.</p>
<h2 class="wp-block-heading" id="h-how-to-create-an-effective-workout-plan"><strong>How to create an effective workout plan?</strong></h2>
<p>An effective exercise plan is essential for achieving your fitness and weight loss goals. A well-balanced plan incorporates different types of exercises, sets realistic goals, and ensures consistent progress. </p>
<p>Here’s how to create an exercise plan that works for you:</p>
<h3 class="wp-block-heading" id="h-1-set-realistic-goals"><strong>1. Set realistic goals</strong></h3>
<p>Setting realistic goals is crucial for maintaining motivation and achieving success in your fitness journey [<a href="https://www.circuit31fitness.com/the-importance-of-setting-realistic-fitness-goals/" target="_blank" rel="noreferrer noopener">3</a>]. Start with the SMART criteria:</p>
<figure class="wp-block-table is-style-stripes"><table><thead><tr><th>SMART criteria</th><th>Description</th><th>Example</th></tr></thead><tbody><tr><td>Specific</td><td>Clearly define your objective</td><td>Lose 10 pounds, run a 5K</td></tr><tr><td>Measurable</td><td>Track progress with specific metrics</td><td>Weight, running time</td></tr><tr><td>Achievable</td><td>Ensure goals are realistic for your level</td><td>Based on current fitness level</td></tr><tr><td>Relevant</td><td>Align goals with overall health aspirations</td><td>Improve health, enhance fitness</td></tr><tr><td>Time-bound</td><td>Set a deadline</td><td>Achieve within three months</td></tr></tbody></table></figure>
<p>Using SMART goals helps create a clear, actionable plan, making it easier to stay on track and motivated.</p>
<h3 class="wp-block-heading" id="h-2-progressive-overload-principle"><strong>2. Progressive overload principle</strong></h3>
<p>The progressive overload principle involves gradually increasing the intensity, duration, or frequency of your workouts to avoid plateaus and continue making progress. Here’s how to apply it:</p>
<ul class="wp-block-list">
<li><strong>Increase weight</strong>: Gradually add more weight to your strength training exercises.</li>
<li><strong>Increase reps or sets</strong>: Add more repetitions or sets to your current routine.</li>
<li><strong>Increase duration</strong>: Extend the length of your cardio sessions.</li>
<li><strong>Increase intensity</strong>: Incorporate more challenging exercises or increase the speed/intensity of your workouts.</li>
</ul>
<p>Progressive overload ensures continuous improvement and helps you achieve your fitness goals more effectively.</p>
<h3 class="wp-block-heading" id="h-3-incorporate-epigenetic-test-insights"><strong>3. Incorporate epigenetic test insights</strong></h3>
<p>Using personalized insights from the <a href="https://longevity.technology/store/epigenetic-dna-test-landing-page/?utm_source=lifestyle&utm_medium=blogs">Longevity.Technology Epigenetic & DNA Test</a> can enhance your workout plan. The test provides tailored recommendations based on your genetic makeup, helping you optimize your exercise routine for better results. </p>
<p>Here’s how to integrate these insights:</p>
<ul class="wp-block-list">
<li><strong>Personalized exercise recommendations: </strong>Adjust your routine based on your genetic predispositions to certain types of exercise.</li>
<li><strong>Nutrition guidance: </strong>Align your diet with your genetic profile to support your fitness goals more effectively.</li>
<li><strong>Recovery insights: </strong>Understand your body’s unique recovery needs and adjust rest days accordingly.</li>
</ul>
<h3 class="wp-block-heading" id="h-4-importance-of-rest-and-recovery"><strong>4. Importance of rest and recovery</strong></h3>
<p>In addition to promoting muscular growth and general health, rest and recuperation are essential for avoiding burnout and injuries. Include <a href="https://longevity.technology/lifestyle/active-recovery-vs-rest-day-10-differences-to-know/" target="_blank" rel="noreferrer noopener">rest days</a> in your schedule to give your body time to mend and rebuild [<a href="https://www.healthline.com/health/exercise-fitness/rest-day" target="_blank" rel="noreferrer noopener">4</a>]. </p>
<p>Listen to your body and rest more if you feel overly fatigued or sore. Make sleep a priority. Aim for 7-9 hours of quality sleep each night to improve muscle repair and refresh your body.</p>
<p>Proper rest ensures sustained progress, reduces the <a href="https://longevity.technology/lifestyle/how-much-does-age-increase-your-injury-risk/" target="_blank" rel="noreferrer noopener">risk of injury</a>, and keeps you energized for future workouts, making it a vital component of any <a href="https://longevity.technology/lifestyle/10-exercises-to-add-to-your-2024-summer-workout-plan/" target="_blank" rel="noreferrer noopener">effective exercise plan</a>.</p>
<figure class="wp-block-image size-large"><img decoding="async" width="1200" height="800" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/an-athletic-man-receiving-a-recovery-massage-by-a-2023-11-27-05-16-47-utc-Unai82-Envato-1200x800.jpg" alt="man on massage table getting massage therapy" class="wp-image-81397"><figcaption class="wp-element-caption">Photograph: Unai82/Envato</figcaption></figure>
<h3 class="wp-block-heading" id="h-5-monitor-your-progress"><strong>5. Monitor your progress</strong></h3>
<p>Monitoring progress helps you stay motivated and adjust your exercise plan. Keep a workout journal to record exercises, weights, sets, reps, and duration. </p>
<p>Use fitness apps to track your workouts, monitor progress, and gain insights. Assess your progress regularly every few weeks to see what’s working and what needs adjustment. </p>
<p>Celebrate small milestones to stay motivated and committed to your goals. Monitoring your progress ensures you stay on track and continue to improve, helping you achieve your fitness and weight loss goals more effectively.</p>
<h3 class="wp-block-heading" id="h-sample-weekly-plan"><strong>Sample weekly plan</strong></h3>
<p>A well-rounded weekly exercise plan balances various workouts to ensure comprehensive fitness and effective weight loss. Here’s a sample plan:</p>
<ul class="wp-block-list">
<li><strong>Monday</strong>: Cardio – Go for a 30-minute run or cycling session. These activities boost cardiovascular health and burn calories efficiently.</li>
<li><strong>Tuesday</strong>: Strength training – Concentrate on weightlifting, using movements like squats, deadlifts, and bench presses to target major muscular areas.</li>
<li><strong>Wednesday</strong>: HIIT – Perform a high-intensity interval training session, such as sprint intervals or circuit training, for 20-30 minutes [<a href="https://www.medicalnewstoday.com/articles/327474" target="_blank" rel="noreferrer noopener">5</a>].</li>
<li><strong>Thursday</strong>: Flexibility and balance – Attend a yoga or Pilates class to improve flexibility, balance, and mental well-being.</li>
<li><strong>Friday</strong>: Cardio – Swim for 30 minutes or jump rope to get your heart rate up and burn calories.</li>
<li><strong>Saturday</strong>: Strength training – Use bodyweight exercises like push-ups, pull-ups, and lunges to build strength and muscle tone.</li>
<li><strong>Sunday</strong>: Rest or light activity – To aid in your body’s healing, give yourself a day off or do mild exercises like walking or moderate stretching.</li>
</ul>
<p>This balanced approach ensures you work on all aspects of fitness, helping you achieve your weight loss and health goals effectively. Adjust the plan as needed to fit your fitness level and preferences.</p>
<h2 class="wp-block-heading" id="h-maximize-weight-loss-with-insights-on-exercise-effect-on-weight-with-longevity-technology-epigenetic-amp-dna-test"><strong>Maximize weight loss with insights on exercise effect on weight with Longevity.Technology Epigenetic & DNA Test</strong></h2>
<p>Understanding how your body responds to exercise can significantly impact your weight loss journey. </p>
<p>The <a href="https://longevity.technology/store/epigenetic-dna-test-landing-page/?utm_source=lifestyle&utm_medium=blogs">Longevity.Technology Epigenetic & DNA Test</a> offers personalized insights that help you optimize your workout routine and dietary habits based on your genetic makeup. The following example shows what you can expect from the test. This sample is illustrative and may differ from your personal results:</p>
<figure class="wp-block-table"><table><tbody><tr><td><strong>DNA results</strong></td><td>Your genetic variants show that you have a normal outcome.</td></tr><tr><td><strong>Recommendations</strong></td><td>This means combining diet and physical activity/exercise is the best way to control weight and lose fat. This is the most common outcome, and even those with beneficial exercise variants must consider diet, but only to a lesser extent. <br>We recommend that you look into your diet to truly understand your weight. However, exercise has multiple other benefits, which does not mean you should neglect it.</td></tr></tbody></table></figure>
<p>With insights from the Longevity.Technology Epigenetic & DNA Test, you can fine-tune your approach to weight loss. Here’s how:</p>
<ul class="wp-block-list">
<li><strong>Balanced exercise approach:</strong> With a normal outcome, a balanced routine that includes both cardio and strength training is essential. This combination helps burn calories, build muscle, and boost metabolism.</li>
<li><strong>Consistency: </strong>Regular exercise, at least 150 minutes of moderate-intensity cardio and two to three strength training sessions per week, supports sustained weight loss.</li>
<li><strong>Dietary adjustments: </strong>Your genetic insights suggest that diet plays a crucial role in weight management. Adopt a balanced diet rich in protein, healthy fats, and complex carbohydrates to fuel your workouts and promote fat loss.</li>
<li><strong>Monitor intake: </strong>Keep track of your caloric intake to ensure you’re not consuming more than you’re burning. Tools like food diaries or nutrition apps can be helpful.</li>
</ul>
<p>Combining the insights from the Longevity.Technology Epigenetic & DNA Test with a consistent exercise routine and mindful eating can significantly enhance your weight loss efforts. This tailored approach ensures that you’re following a generic plan that aligns with your genetic predispositions.</p>
<h2 class="wp-block-heading"><strong>Closing thoughts</strong></h2>
<p>Achieving weight loss through exercise requires a strategic approach. Combining different types of exercises—cardio, strength training, HIIT, and flexibility—ensures a balanced routine that maximizes results. </p>
<p>Setting realistic goals using the SMART criteria helps maintain focus and motivation, while the progressive overload principle keeps you progressing steadily. Start implementing these strategies today and see how they transform your weight loss efforts. </p>
<p>Ready to maximize your weight loss and enhance your overall health? Get the <a href="https://longevity.technology/store/epigenetic-dna-test-landing-page/?utm_source=lifestyle&utm_medium=blogs">Longevity.Technology Epigenetic & DNA Test</a> for personalized insights, optimize your exercise routine, and achieve your wellness goals today!</p>
<h2 class="wp-block-heading"><strong>FAQs</strong></h2>
<h3 class="wp-block-heading"><strong>What is the best type of exercise for weight loss?</strong></h3>
<p>A combination of cardio, strength training, and HIIT works best. This mix ensures you burn calories, build muscle, and boost your metabolism.</p>
<h3 class="wp-block-heading"><strong>How can I stay motivated to work out regularly?</strong></h3>
<p>Set clear, achievable goals and track your progress. Find activities you enjoy and vary your routine to keep things interesting.</p>
<h3 class="wp-block-heading"><strong>Is diet more important than exercise for weight loss?</strong></h3>
<p>Both diet and exercise are crucial for weight loss. Combining a balanced diet with regular exercise yields the best results.</p>
<h3 class="wp-block-heading"><strong>Can I lose weight with just strength training?</strong></h3>
<p>Strength training helps build muscle, which boosts metabolism and aids in weight loss. Combining it with cardio exercises enhances overall results.</p>
<p>[1] <a href="https://www.healthline.com/health/exercise-and-weight-loss" target="_blank" rel="noreferrer noopener">https://www.healthline.com/health/exercise-and-weight-loss</a><br>[2] <a href="https://www.betterhealth.vic.gov.au/health/healthyliving/resistance-training-health-benefits" target="_blank" rel="noreferrer noopener">https://www.betterhealth.vic.gov.au/health/healthyliving/resistance-training-health-benefits</a><br>[3] <a href="https://www.circuit31fitness.com/the-importance-of-setting-realistic-fitness-goals/" target="_blank" rel="noreferrer noopener">https://www.circuit31fitness.com/the-importance-of-setting-realistic-fitness-goals/</a><br>[4] <a href="https://www.healthline.com/health/exercise-fitness/rest-day" target="_blank" rel="noreferrer noopener">https://www.healthline.com/health/exercise-fitness/rest-day</a><br>[5] <a href="https://www.medicalnewstoday.com/articles/327474" target="_blank" rel="noreferrer noopener">https://www.medicalnewstoday.com/articles/327474</a></p>
<h6 class="wp-block-heading" id="h-photograph-seventyfourimages-envato">Photograph: seventyfourimages/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/how-to-leverage-the-exercise-effect-on-weight-for-maximum-loss/">How to leverage the exercise effect on weight for maximum loss</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
New study questions effectiveness of massage for pain relief
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/spa-wellness-and-black-woman-at-couple-massage-fo-2023-11-27-05-14-14-utc-YuriArcursPeopleimages-Envato-1200x800.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="New study questions effectiveness of massage for pain relief" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>A recent study published in <em><a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2821154" target="_blank" rel="noreferrer noopener">JAMA Network Open</a></em> challenges the widely held belief that massage therapy effectively relieves <a href="https://longevity.technology/lifestyle/scientists-discover-pain-feels-different-for-men-and-women/" target="_blank" rel="noreferrer noopener">pain</a>.</p>
<p>This research, which examined the outcomes of numerous clinical trials, found that the evidence supporting massage for pain relief needs to be more convincing than previously thought.</p>
<p>Researchers conducted a comprehensive analysis of existing studies on massage therapy, focusing on its impact on various types of pain, including <a href="https://longevity.technology/lifestyle/whos-chronic-low-back-pain-guidelines-a-new-direction-in-treatment/" target="_blank" rel="noreferrer noopener">chronic back pain</a>, arthritis and postoperative pain. They discovered significant variability in the results, with some studies showing minimal benefits and others indicating no improvement [<a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2821154" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>This inconsistency raises questions about the overall effectiveness of massage as a pain management strategy.</p>
<p>One of the study’s key findings was that massage benefits are often temporary [<a target="_blank" href="https://apm.amegroups.org/article/view/116417/html" rel="noreferrer noopener">2</a>]. Patients may experience a reduction in pain immediately after a session, but this relief tends to be short-lived.</p>
<p>The study suggests that any perceived benefits may be due to the placebo effect or the temporary relaxation that massage provides rather than a lasting reduction in pain.</p>
<p>Additionally, the study highlights the need for standardized protocols in massage therapy research. Different studies used varied techniques, session lengths and frequencies, making it difficult to draw definitive conclusions about massage’s effectiveness.</p>
<p>This inconsistency in methodology suggests the need for more rigorous and standardized research to assess massage therapy’s benefits accurately.</p>
<p>The researchers also pointed out that many studies on massage therapy suffer from biases, such as small sample sizes and lack of blinding, which can skew results. They recommend that future research should focus on larger, well-designed trials to provide more reliable data.</p>
<p>While massage therapy is generally considered safe and can offer short-term relaxation and stress relief, the study urges healthcare providers to consider these findings when recommending massage as a <a href="https://longevity.technology/lifestyle/aspirin-vs-acetaminophen-which-pain-reliever-is-right-for-you/" target="_blank" rel="noreferrer noopener">treatment for pain</a>. Patients should be informed about the limited and inconsistent evidence supporting its efficacy for long-term pain management.</p>
<p>This study questions the effectiveness of massage therapy for pain relief, emphasizing the need for more robust and standardized research. While massage can provide temporary comfort and relaxation, its role in long-term pain management remains uncertain [<a target="_blank" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091428/" rel="noreferrer noopener">3</a>].</p>
<p>Healthcare professionals and patients should be aware of these findings and consider alternative pain management strategies with more consistent evidence of effectiveness.</p>
<p>[1] JAMA Network Open. <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2821154" target="_blank" rel="noreferrer noopener">Use of Massage Therapy for Pain 2018-2023 </a><br>[2] Annals of Palliative Medicine. <a href="https://apm.amegroups.org/article/view/116417/html" target="_blank" rel="noreferrer noopener">Massage therapy in palliative care populations: a narrative review of literature from 2012 to 2022</a><br>[3] International Journal of Therapeutic Massage & Bodywork. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091428/" target="_blank" rel="noreferrer noopener">The Effects of Massage Therapy on Pain Management in the Acute Care Setting</a></p>
<h6 class="wp-block-heading" id="h-photograph-yuriarcurspeopleimages-envato">Photograph: YuriArcursPeopleimages/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/new-study-questions-effectiveness-of-massage-for-pain-relief/">New study questions effectiveness of massage for pain relief</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
Red Deer Project shows how social habits influence aging
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/red-deer-stag-with-new-antlers-growing-covered-in-2023-11-27-05-16-21-utc-WildMediaSK-Envato-1200x800.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="Red Deer Project shows how social habits influence aging" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>Thanks to the dedicated efforts of an international team of researchers, a recent study published in the journal <em><a target="_blank" href="https://www.annualreviews.org/content/journals/10.1146/annurev-ecolsys-012722-024041" rel="noreferrer noopener">Annual Review of Ecology, Evolution, and Systematics</a></em> has shed light on how social habits can significantly influence aging.</p>
<p>The team’s focus on the social behaviors of red deer in the Red Deer Project has provided valuable insights into the aging process.</p>
<p>The study observed red deer over several decades, revealing that <a href="https://longevity.technology/lifestyle/longevity-and-lifestyle-how-social-interactions-contribute-to-longer-life/" target="_blank" rel="noreferrer noopener">social interactions</a> are crucial in determining their lifespan and health. The researchers found that red deer with strong social bonds tend to live longer and maintain better overall health compared to their more isolated counterparts.</p>
<p>These findings suggest that social connections can protect against the negative aspects of aging [<a target="_blank" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583428/" rel="noreferrer noopener">2</a>].</p>
<p>The research team discovered that red deer with more social ties were less susceptible to diseases and exhibited slower <a href="https://longevity.technology/lifestyle/loneliness-or-just-aging-how-lack-of-social-contact-speeds-up-physical-decline/" target="_blank" rel="noreferrer noopener">physical decline</a>. The study emphasized that the quality of social interactions, not just the quantity, is vital for promoting longevity.</p>
<p>Deer that engaged in cooperative behaviors, such as grooming and group foraging, enjoyed <a href="https://longevity.technology/lifestyle/7-simple-steps-to-reverse-your-biological-age-and-boost-longevity/" target="_blank" rel="noreferrer noopener">better health and longevity</a>.</p>
<p>Interestingly, the study also noted that the benefits of social bonds were more pronounced in female deer. Female red deer with extensive social networks showed significant advantages in terms of longevity and health, highlighting the importance of social support in the aging process.</p>
<p>The researchers believe that the findings from the Red Deer Project have significant implications for understanding aging in other species, including humans. The study suggests that fostering strong social connections could be a key <a href="https://longevity.technology/lifestyle/lifestyle-of-superagers-longevity-experts-reveal-their-secrets/" target="_blank" rel="noreferrer noopener">strategy in promoting healthy aging</a>, offering potential applications for human health [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125010/" target="_blank" rel="noreferrer noopener">3</a>].</p>
<p>It emphasizes the potential for social habits to reduce some of the adverse effects of aging, making a compelling case for the importance of social wellbeing.</p>
<p>The Red Deer Project’s findings align with previous research on the benefits of social interactions for health and longevity. By providing a clear example from the animal kingdom, the study reinforces the idea that social bonds are essential for a healthy life.</p>
<p>This research contributes to a growing body of evidence highlighting the interconnectedness of social behavior and aging, offering valuable insights into how <a href="https://longevity.technology/lifestyle/how-longevity-cities-are-shaping-the-future-of-urban-health/" target="_blank" rel="noreferrer noopener">social environments can shape the aging process</a>.</p>
<p>[1] Annual Review of Ecology, Evolution, and Systematics. <a href="https://www.annualreviews.org/content/journals/10.1146/annurev-ecolsys-012722-024041" target="_blank" rel="noreferrer noopener">The Unusual Value of Long-Term Studies of Individuals: The Example of the Isle of Rum Red Deer Project</a><br>[2] American Sociological Review. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583428/" target="_blank" rel="noreferrer noopener">The Social Connectedness of Older Adults: A National Profile</a><br>[3] American Journal of Lifestyle Medicine. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125010/" target="_blank" rel="noreferrer noopener">The Connection Prescription: Using the Power of Social Interactions and the Deep Desire for Connectedness to Empower Health and Wellness</a></p>
<h6 class="wp-block-heading" id="h-photograph-wildmediask-envato">Photograph: WildMediaSK/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/red-deer-project-shows-how-social-habits-influence-aging/">Red Deer Project shows how social habits influence aging</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>
SARS-CoV-2 activates cell death pathways in human airways
<div><img width="525" height="350" src="https://longevity.technology/lifestyle/wp-content/uploads/2024/07/image-of-flu-virus-cell-under-the-microscope-on-th-2023-11-27-05-05-49-utc-IciakPhotos-Envato.jpg" class="webfeedsFeaturedVisual wp-post-image" alt="SARS-CoV-2 activates cell death pathways in human airways" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" sizes="100vw">
<p>SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has demonstrated a profound ability to induce cell death in the human airway epithelium. </p>
<p>Cell death, a fundamental biological process, can occur through several pathways, including apoptosis, necroptosis, and pyroptosis. Each pathway plays a unique role in maintaining cellular homeostasis and responding to pathogenic threats.</p>
<p>Cell death pathways have long been the focus of research, given their critical roles in disease and health. Understanding these pathways becomes even more pertinent in the context of viral infections. </p>
<p>The SARS-CoV-2 pandemic has underscored the need for detailed knowledge of how viruses manipulate host cell processes to cause disease [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>Historically, apoptosis was the first cell death pathway to be extensively studied. Necroptosis and pyroptosis, which are more inflammatory, have gained attention more recently, especially concerning infectious diseases and cancer. </p>
<h2 class="wp-block-heading" id="h-apoptosis-the-programmed-cell-death"><strong>Apoptosis: The programmed cell death</strong></h2>
<p>Apoptosis is a highly regulated process that allows cells to die in a controlled manner, preventing the release of harmful substances into the surrounding tissue. </p>
<p>This process is typically marked by cellular shrinkage, DNA fragmentation, and the formation of apoptotic bodies, which are then engulfed and digested by phagocytic cells [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<h2 class="wp-block-heading" id="h-necroptosis-the-inflammatory-cell-death"><strong>Necroptosis: The inflammatory cell death</strong></h2>
<p>Necroptosis, on the other hand, is a form of programmed necrosis that releases cellular contents, causing inflammation. </p>
<p>This pathway is characterized by the formation of pores in the cell membrane through the action of mixed lineage kinase domain-like pseudokinase (MLKL) following its phosphorylation by receptor-interacting protein kinases (RIPK1 and RIPK3) [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<h2 class="wp-block-heading" id="h-pyroptosis-the-fiery-cell-death"><strong>Pyroptosis: The fiery cell death</strong></h2>
<p>Pyroptosis is an inflammatory form of cell death driven by the activation of inflammasomes and the cleavage of gasdermin proteins. These proteins create pores in the cell membrane, leading to cell lysis and the release of pro-inflammatory cytokines such as IL-1β [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<h2 class="wp-block-heading" id="h-sars-cov-2-and-cell-death-pathways"><strong>SARS-CoV-2 and cell death pathways</strong></h2>
<p>Research led by Kaixin Liang and colleagues has uncovered that SARS-CoV-2 activates all three major cell death pathways—apoptosis, necroptosis, and pyroptosis—in the human airway epithelium. </p>
<p>These findings are critical for understanding how the <a href="https://longevity.technology/lifestyle/how-covid-is-still-creating-a-generation-of-chronic-illness/" target="_blank" rel="noreferrer noopener">virus causes damage</a> and contributes to severe COVID-19 symptoms [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<h3 class="wp-block-heading" id="h-study-findings"><strong>Study findings</strong></h3>
<p>The study utilized a combination of primary human airway epithelial cultures and animal models to investigate the cell death response to SARS-CoV-2 infection. </p>
<p>It was observed that SARS-CoV-2 induces necroptosis primarily in infected cells, while uninfected bystander cells undergo apoptosis. Pyroptosis occurs later in the infection process [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>The key findings include:</p>
<ul class="wp-block-list">
<li><strong>Necroptosis:</strong> Infected cells showed significant phosphorylation of MLKL, indicating active necroptosis. This process is triggered by the viral Z-RNA binding to Z-DNA-binding protein 1 (ZBP1), which interacts with RIPK3 to initiate the necroptotic cascade [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</li>
</ul>
<ul class="wp-block-list">
<li><strong>Apoptosis:</strong> Bystander cells that were not directly infected by the virus exhibited markers of apoptosis, such as caspase-3 cleavage. This indicates that apoptosis might be a secondary <a href="https://longevity.technology/lifestyle/can-covid-19-infection-disrupt-the-balance-of-the-guts-microbiome/" target="_blank" rel="noreferrer noopener">effect of the viral infection</a>, possibly due to the inflammatory environment created by the necroptotic cells [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</li>
</ul>
<ul class="wp-block-list">
<li><strong>Pyroptosis:</strong> This form of cell death, marked by gasdermin D (GSDMD) cleavage, occurs later in the infection timeline, contributing to the inflammatory response seen in severe COVID-19 cases [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</li>
</ul>
<p>The activation of necroptosis, in particular, suggests potential therapeutic targets. Inhibitors of RIPK1 and MLKL, key proteins in the necroptotic pathway, could be explored as treatments to prevent the extensive tissue damage observed in <a href="https://longevity.technology/lifestyle/study-explains-why-covid-19-is-more-fatal-to-seniors/" target="_blank" rel="noreferrer noopener">severe COVID-19 cases</a>. </p>
<p>Additionally, modulating the inflammasome activation and pyroptosis could reduce the inflammatory response, potentially alleviating some of the severe symptoms associated with the virus [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>While these findings are promising, they highlight the complexity of the <a href="https://longevity.technology/lifestyle/new-study-explains-why-some-people-are-more-susceptible-to-covid-19-while-others-are-not/" target="_blank" rel="noreferrer noopener">body’s response to SARS-CoV-2</a>. </p>
<p>The interplay between different cell death pathways and the timing of their activation presents challenges for developing effective treatments. </p>
<p>Further research is needed to understand these pathways’ precise triggers and regulatory mechanisms in the context of COVID-19 [<a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">1</a>].</p>
<p>[1] Science Immunology. <a href="https://www.science.org/doi/10.1126/sciimmunol.adn0178" target="_blank" rel="noreferrer noopener">Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium</a></p>
<h6 class="wp-block-heading" id="h-photograph-iciakphotos-envato">Photograph: IciakPhotos/Envato</h6>
<p>The post <a href="https://longevity.technology/lifestyle/sars-cov-2-activates-cell-death-pathways-in-human-airways/">SARS-CoV-2 activates cell death pathways in human airways</a> appeared first on <a href="https://longevity.technology/lifestyle">Longevity.Technology Lifestyle | Health, Fitness & Technology</a>.</p></div>